About: Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques

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About: Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques
Creator	Baudart, Sébastien Bayat, Babak Brauers, Geoffroy Clarinval, Géraldine Cohen, Joe Donner, Marie-Noëlle Koutsoukos, Marguerite Lorin, Clarisse Marchand, Martine Mettens, Pascal Ska, Michaël Vanloubbeeck, Yannick Voss, Gerald
Source	PMC
abstract	HIV-1-specific CD4(+) and CD8(+) T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4(+) T-cell responses in humans. While replication-incompetent recombinant HIV-1/SIV antigen-expressing human adenoviral vectors can elicit high-frequency antigen-specific CD8(+) T-cell responses, their use is hampered by widespread pre-existing immunity to human serotypes. Non-human adenovirus serotypes associated with lower prevalence may offer an alternative strategy. We evaluated the immunogenicity of AdC7-GRN (‘A’), a recombinant chimpanzee adenovirus type 7 vector expressing clade B Gag, RT and Nef, and F4/AS01 (‘P’), when delivered intramuscularly in homologous (PP or AA) and heterologous (AAPP or PPAA) prime-boost regimens, in macaques and mice. Vaccine-induced HIV-1-antigen-specific T cells in peripheral blood (macaques), liver, spleen, and intestinal and genital mucosa (mice) were characterized by intracellular cytokine staining. Vaccine-specific IgG antibodies (macaques) were detected using ELISA. In macaques, only the heterologous prime-boost regimens induced polyfunctional, persistent and balanced CD4(+) and CD8(+) T-cell responses specific to each HIV-1 vaccine antigen. AdC7-GRN priming increased the polyfunctionality of F4/AS01-induced CD4(+) T cells. Approximately 50% of AdC7-GRN-induced memory CD8(+) T cells exhibited an effector-memory phenotype. HIV-1-specific antibodies were detected with each regimen. In mice, antigen-specific CD4(+) and CD8(+) T-cell responses were detected in the mucosal and systemic anatomical compartments assessed. When administered in heterologous prime-boost regimens, AdC7-GRN and F4/AS01 candidate vaccines acted complementarily in inducing potent and persistent peripheral blood HIV-1-specific CD4(+) and CD8(+) T-cell responses and antibodies in macaques. Besides, adenoviral vector priming modulated the cytokine-expression profile of the protein-induced CD4(+) T cells. Each regimen induced HIV-1-specific T-cell responses in systemic/local tissues in mice. This suggests that prime-boost regimens combining adjuvanted protein and low-seroprevalent chimpanzee adenoviral vectors represent an attractive vaccination strategy for clinical evaluation.
has issue date	2015-04-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0122835
bibo:pmid	25856308
has license	cc-by
sha1sum (hex)	f0f627b8e856fdf97cf414ac42f3536ff1a33134
schema:url	https://doi.org/10.1371/journal.pone.0122835
resource representing a document's title	Heterologous Prime-Boost Regimens with a Recombinant Chimpanzee Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional HIV-1-Specific T-Cell Responses in Macaques
has PubMed Central identifier	PMC4391709
has PubMed identifier	25856308
schema:publication	PLoS One
resource representing a document's body	covid:f0f627b8e856fdf97cf414ac42f3536ff1a33134#body_text
is schema:about of	named entity 'liver' named entity 'prime-boost' named entity 'memory' named entity 'mice' named entity 'Gag' named entity 'CD4' named entity 'inducing' named entity 'antigen' named entity 'p24' named entity 'CD8' named entity 'HIV-1' named entity 'clade' named entity 'Adenoviral' named entity 'Protein' named entity 'REGIMENS' named entity 'CLADE' covid:arg/f0f627b8e856fdf97cf414ac42f3536ff1a33134 named entity 'RECOMBINANT' named entity 'PERSISTENT' named entity 'T-CELL' named entity 'SEROTYPES' named entity 'ANTIBODIES' named entity 'HUMAN' named entity 'T LYMPHOCYTES' named entity 'MACAQUES' named entity 'BOOST' named entity 'STRATEGY' named entity 'GRN' named entity 'VACCINE' named entity 'ADMINISTERED' named entity 'BALANCED' named entity 'LOWER' named entity 'ELICIT' named entity '27A' named entity 'SYSTEMIC' named entity 'USE' named entity 'MEMORY' named entity 'MODULATED' named entity 'ADENOVIRUS TYPE 7' named entity 'PRIME' named entity 'VACCINE ANTIGEN' named entity 'REPLICATION' named entity 'SPECIFIC' named entity 'SYSTEM' named entity 'FUSION PROTEIN' named entity 'THEIR' named entity 'VECTORS' named entity 'LIVER' named entity 'COMPARTMENTS' named entity 'CANDIDATE' named entity 'POL' named entity 'ADJUVANTED' named entity 'RESPONSES' named entity 'CHIMPANZEE' named entity 'HETEROLOGOUS' named entity 'T-CELL' named entity 'PROTEIN ' named entity 'MACAQUES' named entity 'HIV-1' named entity 'CHARACTERIZED' named entity 'RESPONSES' named entity 'CONTROL' named entity 'INDUCED' named entity 'SPLEEN' named entity 'INDUCING' named entity 'IMMUNOGENICITY' named entity 'GAG' named entity 'PERIPHERAL BLOOD' named entity 'APPROXIMATELY'

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