About: Activation of the Antiviral Kinase PKR and Viral Countermeasures

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activation of the Antiviral Kinase PKR and Viral Countermeasures
Creator	Wolff, Thorsten Dauber, Bianca
Source	Medline; PMC
abstract	The interferon-induced double-stranded (ds)RNA-dependent protein kinase (PKR) limits viral replication by an eIF2α-mediated block of translation. Although many negative-strand RNA viruses activate PKR, the responsible RNAs have long remained elusive, as dsRNA, the canonical activator of PKR, has not been detected in cells infected with such viruses. In this review we focus on the activating RNA molecules of different virus families, in particular the negative-strand RNA viruses. We discuss the recently identified non-canonical activators 5′-triphosphate RNA and the vRNP of influenza virus and give an update on strategies of selected RNA and DNA viruses to prevent activation of PKR.
has issue date	2009-10-27(xsd:dateTime)
bibo:doi	10.3390/v1030523
bibo:pmid	21994559
has license	cc-by
sha1sum (hex)	f0d935a0e0f1360bf4166b9db8e4cddf67aa9cd7
schema:url	https://doi.org/10.3390/v1030523
resource representing a document's title	Activation of the Antiviral Kinase PKR and Viral Countermeasures
has PubMed Central identifier	PMC3185532
has PubMed identifier	21994559
schema:publication	Viruses
resource representing a document's body	covid:f0d935a0e0f1360bf4166b9db8e4cddf67aa9cd7#body_text
is schema:about of	named entity 'ACTIVATION' named entity 'VIRAL' named entity 'cells' named entity 'viral replication' named entity 'RNA' named entity 'PKR' named entity 'RNAs' named entity 'RNA' named entity 'ANTIVIRAL' named entity 'DIFFERENT' named entity 'UPDATE' named entity 'ACTIVATE' named entity 'EIF2' named entity 'TRANSLATION' named entity 'RECENTLY' named entity 'PROTEIN KINASE' named entity 'CELLS' named entity 'STRATEGIES' named entity 'VIRUS' named entity 'PKR' named entity 'INFECTED' named entity 'PARTICULAR' named entity 'RESPONSIBLE' named entity 'KINASE' named entity 'RNA VIRUSES' named entity 'NON-' named entity 'DSRNA' named entity 'FAMILIES' named entity 'DOUBLE' named entity 'LONG' named entity 'ACTIVATION' named entity 'BLOCK' named entity 'DISCUSS' named entity 'INDUCED' named entity 'SELECTED' named entity 'HAVE' named entity 'IDENTIFIED' named entity 'PKR' named entity 'VIRUSES' named entity 'DETECTED' named entity 'RNAS' named entity 'REVIEW' named entity 'VRNP' named entity 'DNA VIRUSES' named entity 'INTERFERON' named entity 'STRAND' named entity 'TO PREVENT' named entity 'MOLECULES' named entity 'MEDIATED' named entity 'FOCUS' named entity 'ACTIVATING' named entity 'DEPENDENT' named entity 'VIRAL REPLICATION' named entity 'LIMITS' named entity 'TRIPHOSPHATE' named entity 'INFLUENZA VIRUS' named entity 'ACTIVATOR OF' named entity 'NEGATIVE' named entity 'RNA' named entity 'activation' named entity 'molecules' named entity 'long' named entity 'remained' named entity 'Although' named entity 'focus' named entity 'virus' named entity 'RNA viruses' named entity 'double-stranded' named entity 'vRNP' named entity 'update' named entity 'viruses' named entity 'rapid evolution' named entity 'kinase' named entity 'binding region' named entity 'virus' named entity 'N-terminal' named entity 'Hantaan virus' named entity 'cytosolic' named entity 'upregulated' named entity 'fibroblasts'

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