About: The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

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About: The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
Creator	Chen, Xiao Eisen, Michael Barrington, Chloe Bilodeau, Danielle Dzitoyeva, Svetlana Henriksen, Jesslyn Rissland, Olivia Rutt, Lauren Wang, Miranda Zavortink, Michael
Source	PMC
abstract	The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found that three maternally deposited Drosophila RNA-binding proteins (ME31B, Trailer Hitch [TRAL], and Cup) are also cleared during the MZT by unknown mechanisms. Here, we show that these proteins are degraded by the ubiquitin-proteasome system. Marie Kondo, an E2 conjugating enzyme, and the E3 CTLH ligase are required for the destruction of ME31B, TRAL, and Cup. Structure modeling of the Drosophila CTLH complex suggests that substrate recognition is different than orthologous complexes. Despite occurring hours earlier, egg activation mediates clearance of these proteins through the Pan Gu kinase, which stimulates translation of Kdo mRNA. Clearance of the maternal protein dowry thus appears to be a coordinated, but as-yet underappreciated, aspect of the MZT.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.7554/elife.53889
bibo:pmid	32573431
has license	cc-by
sha1sum (hex)	f07bbd68c04bb1f47c009ef9ea5bd221128e647a
schema:url	https://doi.org/10.7554/elife.53889
resource representing a document's title	The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition
has PubMed Central identifier	PMC7384856
has PubMed identifier	32573431
resource representing a document's body	covid:f07bbd68c04bb1f47c009ef9ea5bd221128e647a#body_text
is schema:about of	named entity 'kinase' named entity 'RNA-binding proteins' named entity 'transcriptome' named entity 'mRNA' named entity 'Drosophila' named entity 'protein' named entity 'Marie Kondo' named entity 'RNA binding proteins' named entity 'egg laying' named entity 'RNAi' named entity 'upregulation' named entity 'endogenous' named entity 'RNA immunoprecipitation' named entity 'S. cerevisiae' named entity 'egg activation' named entity 'RNase' named entity 'messenger RNAs' named entity 'mass spectrometry' named entity 'fusion genes' named entity 'kinase' named entity 'western blot' named entity 'phosphorylating' named entity 'phosphorylates' named entity 'E3 ligases' named entity 'zygotic' named entity 'genome' named entity 'E3 ligases' named entity 'lysates' named entity 'embryo' named entity 'enzyme' named entity 'budding yeast' named entity 'kinase' named entity 'reagent' named entity 'GFP fluorescence' named entity 'MZT' named entity 'kinase' named entity 'egg activation' named entity 'GFP' named entity 'fluorescence' named entity 'PNG' named entity 'genetic control' named entity 'unfertilized eggs' named entity 'TRAL' named entity 'E. Izaurralde' named entity 'PNG' named entity 'PNG' named entity 'phosphorylation' named entity 'RNA-binding protein' named entity 'antibodies' named entity 'eIF4E' named entity 'oocyte' named entity 'GFP' named entity 'egg laying' named entity 'PNG' named entity 'allele' named entity 'polyubiquitin' named entity 'RNA' named entity 'TRAL' named entity 'GFP' named entity 'MZT' named entity 'homologs' named entity 'pull-down' named entity 'homogenized' named entity 'mRNA' named entity 'yeast' named entity 'PNG' named entity 'western blotting' named entity 'PNG' named entity 'SDS-PAGE' named entity 'egg activation' named entity 'substrate' named entity 'E3 ligases' named entity 'yeast'

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