About: Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus

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About: Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus
Creator	Jung, Kwonil Kang, Bo-Kyu Kim, Jeom-Yong Lee, Chul-Seung Shin, Kyoung-Sun Song, Dae-Sub
Source	Elsevier; Medline; PMC
abstract	Abstract Epidermal growth factor (EGF) promotes gastrointestinal mucosal recovery by stimulating the mitogenic activity of intestinal crypt epithelial cells. The aim of this study was to determine the effects of EGF on atrophic enteritis induced in piglets by experimental infection with porcine epidemic diarrhoea virus (PEDV) strain Dr13. Two groups of 12 conventional, colostrum-deprived, 1-day-old, large White-Duroc cross breed piglets were inoculated orally with PEDV (3×105 50% tissue culture infective doses), with or without EGF (10μg/kg/day, intraperitoneally once daily for 4 days after infection) and compared to 12 uninfected, untreated control piglets. PEDV+EGF piglets had less severe clinical signs than PEDV only piglets at 48 and 60h post-infection (hpi). Histologically, the ratio of villous height:crypt depth of PEDV+EGF piglets was significantly higher than PEDV only piglets at 36 and 48hpi. Immunohistochemistry for Ki67 demonstrated increased proliferation in intestinal crypt epithelial cells of PEDV+EGF piglets compared to PEDV only piglets at 36, 48 and 60hpi. EGF stimulates proliferation of intestinal crypt epithelial cells and promotes recovery from atrophic enteritis in PEDV-infected piglets.
has issue date	2008-08-31(xsd:dateTime)
bibo:doi	10.1016/j.tvjl.2007.04.018
bibo:pmid	17574457
has license	els-covid
sha1sum (hex)	f0697312e0364b6dfc79845ced5fb206cddcf43f
schema:url	https://doi.org/10.1016/j.tvjl.2007.04.018
resource representing a document's title	Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus
has PubMed Central identifier	PMC7129753
has PubMed identifier	17574457
schema:publication	The Veterinary Journal
resource representing a document's body	covid:f0697312e0364b6dfc79845ced5fb206cddcf43f#body_text
is schema:about of	named entity 'ATROPHIC' named entity 'stimulates' named entity 'EGF' named entity 'piglets' named entity 'atrophic' named entity 'demonstrated' named entity 'intestinal crypt' named entity 'piglets' named entity 'virus' named entity 'EPIDERMAL GROWTH FACTOR' named entity 'EFFECTS' named entity 'GROUPS' named entity 'GASTROINTESTINAL' named entity 'INFECTION' named entity 'RECOVERY' named entity 'CONVENTIONAL' named entity 'INTESTINAL CRYPT' named entity 'RATIO' named entity 'SEVERE' named entity 'DAY-OLD' named entity 'VILLOUS' named entity 'ENTERITIS' named entity 'DR13' named entity 'MUCOSAL' named entity 'HPI' named entity 'DEMONSTRATED' named entity 'DAYS' named entity 'MITOGENIC ACTIVITY' named entity '50%' named entity 'EPIDERMAL GROWTH FACTOR' named entity 'EXPERIMENTAL INFECTION' named entity 'STIMULATING' named entity 'KI67' named entity 'ATROPHIC' named entity 'BREED' named entity 'EPITHELIAL CELLS' named entity 'CROSS' named entity 'EXPERIMENTAL' named entity 'DETERMINE' named entity 'CONTROL' named entity 'DOSES' named entity 'ENTERITIS' named entity 'INDUCED' named entity 'INCREASED PROLIFERATION' named entity 'HEIGHT' named entity 'INDUCED' named entity 'STUDY' named entity 'AIM' named entity 'PORCINE EPIDEMIC DIARRHOEA VIRUS' named entity 'PROLIFERATION' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'EFFECTS' named entity 'HIGHER' named entity 'UNINFECTED' named entity 'ORALLY' named entity 'PEDV' named entity 'COMPARED' named entity 'STRAIN' named entity 'EGF' named entity 'TISSUE CULTURE' named entity '283' named entity 'HISTOLOGICALLY' named entity 'PORCINE EPIDEMIC DIARRHOEA VIRUS' named entity 'DUROC' named entity 'DEPTH' named entity 'LARGE WHITE' named entity 'UNTREATED' named entity 'COLOSTRUM' named entity 'ONCE DAILY' named entity 'INFECTED' named entity 'POST' covid:arg/f0697312e0364b6dfc79845ced5fb206cddcf43f named entity 'piglets' named entity 'proliferation' named entity 'cross breed' named entity 'infection'

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