About: Sensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazil

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About: Sensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazil Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazil
Creator	Tovo-Rodrigues, Luciana Dellagostin, Odir Hallal, Pedro Ferreira, Alves Aluísio, Jardim Campos Pellanda, Lucia Dornellas De Barros, Freitas Da Silveira, Mariangela Gomes Victora, Cesar John, Alan Mcbride, Alexander Márcia, Eliana Pellanda, Lucia Roberto, Marcos Wendland, Ros
Source	MedRxiv
abstract	Background: While the recommended laboratory diagnosis of COVID-19 is a molecular based assay, population-based studies to determine the prevalence of COVID-19 usually use serological assays. Objective: To evaluate the sensitivity and specificity of a rapid diagnostic test for COVID-19 compared to quantitative reverse transcription polymerase chain reaction (qRT-PCR). Methods: We evaluated the sensitivity using a panel of finger prick blood samples from participants >18 years of age that had been tested for COVID-19 by qRT-PCR. For assessing specificity, we used serum samples from the 1982 Pelotas (Brazil) Birth Cohort participants collected in 2012 with no exposure to SARS-CoV-2. Results: The sensitivity of the test was 77.1% (95% CI 66.6 - 85.6), based upon 83 subjects who had tested positive for qRT-PCR at least 10 days before the rapid diagnostic test (RDT). Based upon 100 sera samples, specificity was 98.0% (95% CI 92.9 - 99.8). There was substantial agreement (Kappa score 0.76) between the qRT-PCR results and the RDT. Interpretation. The validation results are well in line with previous assessments of the test, and confirm that it is sufficiently precise for epidemiological studies aimed at monitoring levels and trends of the COVID-19 pandemic.
has issue date	2020-05-10(xsd:dateTime)
bibo:doi	10.1101/2020.05.06.20093476
has license	medrxiv
sha1sum (hex)	f05af49ada9f74c8c1052cb1b84f0f0e2db68c67
schema:url	https://doi.org/10.1101/2020.05.06.20093476
resource representing a document's title	Sensitivity and specificity of a rapid test for assessment of exposure to SARS-CoV-2 in a community-based setting in Brazil
resource representing a document's body	covid:f05af49ada9f74c8c1052cb1b84f0f0e2db68c67#body_text
is schema:about of	named entity 'test' named entity 'participants' named entity 'substantial' named entity '95% CI' named entity 'RDT' named entity 'RESULTS' named entity 'PELOTAS' named entity 'SERUM' named entity 'SCORE 0' named entity 'SARS-COV-2' named entity 'DETERMINE' named entity 'METHODS' named entity 'COMPARED' named entity 'QUANTITATIVE REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION' named entity 'STUDIES' named entity 'LEVELS' named entity 'PARTICIPANTS' covid:arg/f05af49ada9f74c8c1052cb1b84f0f0e2db68c67 named entity 'qRT-PCR' named entity 'determine' named entity 'based' named entity 'specificity' named entity 'specificity' named entity 'collected' named entity 'monitoring' named entity 'sensitivity' named entity 'panel' named entity 'RDT' named entity 'sera' named entity 'qRT-PCR' named entity 'COVID-19 pandemic' named entity 'assay' named entity 'Pelotas' named entity 'SARS-CoV-2' named entity 'RDT' named entity 'sensitivity and specificity' named entity 'reverse transcription polymerase chain reaction' named entity 'SARS-CoV-2' named entity 'rapid test' named entity 'Sensitivity and specificity' named entity 'qRT-PCR' named entity 'RDT' named entity 'SARS-CoV-2' named entity 'sensitivity and specificity' named entity 'SARS-CoV-2' named entity 'Federal University of Pelotas' named entity 'randomly selected' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'COVID-19.' named entity 'RDT' named entity 'SARS-CoV-2' named entity 'epidemiology' named entity '21%' named entity 'COVID-19' named entity 'public health' named entity 'IgM' named entity 'Ostend' named entity 'IgG' named entity 'Serological tests' named entity 'infection' named entity 'Porto Alegre' named entity 'preprint' named entity '95% CI' named entity 'mortality rates' named entity 'RDT' named entity 'qRT-PCR' named entity 'MedCalc' named entity 'Antibody Test' named entity 'SARS-CoV-2' named entity 'serum samples'

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