About: Interferon lambda inhibits dengue virus replication in epithelial cells

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About: Interferon lambda inhibits dengue virus replication in epithelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon lambda inhibits dengue virus replication in epithelial cells
Creator	Flores-Mendoza, Lilian Herrera-Camacho, Irma Reyes-Leyva, Julio Santos-López, Gerardo Vallejo-Ruiz, Verónica Flores-Alonso, Juan Palma-Ocampo, Helen Rosas-Murrieta, Nora
Source	Medline; PMC
abstract	BACKGROUND: In viral disease, infection is controlled at the cellular level by type I interferon (IFN-I), but dengue virus (DENV) has the ability to inhibit this response. Type III interferon, also known as lambda IFN (IFN-III or IFN-λ), is a complementary pathway to the antiviral response by IFN-I. This work analyzed the IFN-λ (IFN-III) mediated antiviral response against DENV serotype 2 (DENV-2) infection. METHODS: Dengue fever patients were sampled to determine their IFN-λ levels by ELISA. To study the IFN-λ response during DENV infection we selected the epithelial cell line C33-A, and we demonstrated that it is permissive to DENV-2 infection. The effect of IFN-λ on virus replication was determined in these cells, in parallel to the expression of IFN-stimulated genes (ISGs), and Suppressor of Cytokine Signaling (SOCS), genes measured by RT-qPCR. RESULTS: We found increased (~1.8 times) serological IFN-λ in dengue fever patients compared to healthy blood donors. IFN-λ inhibited DENV-2 replication in a dose-dependent manner in vitro. The reduction of viral titer corresponded with increased ISG mRNA levels (MX1 and OAS1), with the highest inhibition occurring at ISG’s peak expression. Presence of IFN-negative regulators, SOCS1 and SOCS3, during DENV-2 infection was associated with reduced IFN-λ1 expression. CONCLUSIONS: Evidence described here suggests that IFN-λ is a good candidate inhibitor of viral replication in dengue infection. Mechanisms for the cellular and organismal interplay between DENV and IFN- λ need to be further studied as they could provide insights into strategies to treat this disease. Furthermore, we report a novel epithelial model to study dengue infection in vitro.
has issue date	2015-09-28(xsd:dateTime)
bibo:doi	10.1186/s12985-015-0383-4
bibo:pmid	26411318
has license	cc-by
sha1sum (hex)	f057fa2845067210cbd31e79d8a83cdff0aa96f1
schema:url	https://doi.org/10.1186/s12985-015-0383-4
resource representing a document's title	Interferon lambda inhibits dengue virus replication in epithelial cells
has PubMed Central identifier	PMC4584467
has PubMed identifier	26411318
schema:publication	Virol J
resource representing a document's body	covid:f057fa2845067210cbd31e79d8a83cdff0aa96f1#body_text
is schema:about of	named entity 'VIRUS REPLICATION' named entity 'dengue' named entity 'infection' named entity 'expression' named entity 'times' named entity 'Suppressor' named entity 'treat' named entity 'replication' named entity 'dengue virus' named entity 'RT-QPCR' named entity 'ELISA' named entity 'MEASURED' named entity 'SOCS3' named entity 'TIMES' named entity 'THEIR' named entity 'CONCLUSIONS' named entity 'NOVEL' named entity 'TO INHIBIT' named entity 'INFECTION' named entity 'IN VITRO' named entity 'SOCS1' named entity 'DENGUE INFECTION' named entity 'MEDIATED' named entity 'NEGATIVE' named entity '1.8' named entity 'DENV-2' named entity 'DISEASE' named entity 'CANDIDATE' named entity 'MRNA' named entity 'DETERMINE' named entity 'INSIGHTS' named entity 'LAMBDA' named entity 'INCREASED' named entity 'BACKGROUND' named entity 'COMPARED' named entity 'MECHANISMS' named entity 'GOOD' named entity 'VIRUS REPLICATION' named entity 'OAS1' named entity 'SUPPRESSOR OF CYTOKINE SIGNALING' named entity 'NEED' named entity 'STUDY' named entity 'PEAK' named entity 'BLOOD DONORS' named entity 'FOUND' named entity 'PARALLEL TO' named entity 'REDUCED' named entity 'WORK' named entity 'INHIBITION' named entity 'TREAT' named entity 'SEROTYPE' named entity 'ANTIVIRAL RESPONSE' named entity 'RESULTS' named entity '27S' named entity 'EPITHELIAL CELL LINE' named entity 'KNOWN' named entity 'REPORT' named entity 'PATIENTS' named entity 'ISG' named entity 'PRESENCE OF' named entity 'EXPRESSION' named entity 'CELLULAR' named entity 'LEVELS' named entity 'VIRAL TITER' named entity 'EVIDENCE' named entity 'DENGUE VIRUS' named entity 'ORGANISMAL' named entity 'EFFECT' named entity 'STRATEGIES' named entity 'SELECTED' named entity 'METHODS' named entity 'HIGHEST' named entity 'SEROLOGICAL' named entity 'INHIBITOR'

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