About: Peptides with 16R in S2 protein showed broad reactions with sera against different types of infectious bronchitis viruses

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About: Peptides with 16R in S2 protein showed broad reactions with sera against different types of infectious bronchitis viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Peptides with 16R in S2 protein showed broad reactions with sera against different types of infectious bronchitis viruses
Creator	Shao, Hongxia Ye, Jianqiang Qian, Kun Qin, Aijian Lin, Zhixian Wu, Qi
Source	Elsevier; Medline; PMC
abstract	Vaccination plays a vital role in controlling diseases caused by chicken infectious bronchitis virus (IBV). The continuously variant antigenicity of IBV limits the application of current vaccine strategies and serological diagnostic systems. S2 protein is an invariant that harbors broad neutralizing epitopes. However, little is known about the key amino acids that contribute to the broad-spectrum S2 epitopes. In this study, we aimed to elucidate the specific amino acids contributing to S2 epitopes. Site mutagenesis and peptide-based enzyme-linked immunosorbent assays (ELISAs) showed that 16R in S2 protein was a key amino acid mediating the antigenicity of S2 protein. S2-derived peptides with 16R, but not those with 16 K, could react with sera against different types of IBVs. Notably, a commercial ELISA kit for detection of antibodies against IBV did not react with sera against all types of IBVs. Taken together, these data demonstrated that S2-derived peptides with 16R could be used as novel marker-based antigens for developing both broad-spectrum vaccines and serological diagnostic kits to control IBV.
has issue date	2019-08-16(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.108391
bibo:pmid	31500728
has license	no-cc
sha1sum (hex)	f04f0f5b24ca0cf9715ab7ac7600d52e48aef120
schema:url	https://doi.org/10.1016/j.vetmic.2019.108391
resource representing a document's title	Peptides with 16R in S2 protein showed broad reactions with sera against different types of infectious bronchitis viruses
has PubMed Central identifier	PMC7117385
has PubMed identifier	31500728
schema:publication	Vet Microbiol
resource representing a document's body	covid:f04f0f5b24ca0cf9715ab7ac7600d52e48aef120#body_text
is schema:about of	named entity 'VIRUSES' named entity 'study' named entity 'enzyme-linked immunosorbent assays' named entity 'sera' named entity 'Peptides' named entity 'DIFFERENT' named entity 'CURRENT' named entity 'MUTAGENESIS' named entity 'STRATEGIES' named entity 'THESE' named entity 'TYPES' named entity 'STUDY' named entity 'CAUSED BY' named entity 'SYSTEMS' named entity 'AMINO ACIDS' named entity 'CONTRIBUTING' named entity 'DETECTION' named entity 'PROTEIN' named entity 'DIAGNOSTIC' named entity 'SERA' named entity 'VITAL' named entity 'VACCINE' named entity 'BROAD' named entity 'REACTIONS' named entity 'TYPES' named entity 'INFECTIOUS BRONCHITIS' named entity 'PEPTIDES' named entity 'PROTEIN ' named entity 'ABOUT' named entity 'SERA' named entity 'PROTEIN ' named entity 'APPLICATION' named entity 'KEY' named entity 'MEDIATING' named entity 'PLAYS' named entity 'EPITOPES' named entity 'NOVEL' named entity 'BROAD' named entity 'KIT' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'TO CONTROL' named entity 'BUT' named entity 'LIMITS' named entity 'VACCINATION' named entity 'DID' named entity 'ANTIGENICITY' named entity 'WAS A' named entity 'COULD BE' named entity 'KNOWN' named entity 'ELISA' named entity 'SEROLOGICAL' named entity 'TAKEN' named entity 'ANTIGENS' named entity 'ROLE' named entity 'USED' named entity 'MARKER' named entity 'AMINO ACID' named entity 'CONTROLLING' named entity 'SPECTRUM' named entity 'COMMERCIAL' named entity 'CONTRIBUTE ' named entity 'PEPTIDES' named entity 'CHICKEN' named entity 'DEMONSTRATED' named entity 'DISEASES' named entity 'SITE' named entity 'ANTIBODIES' named entity 'DIFFERENT' named entity 'LITTLE' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAYS' named entity 'DATA' named entity 'SPECIFIC' named entity 'INVARIANT' named entity 'DEVELOPING' named entity 'VACCINES' named entity 'BASED'

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