About: Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

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About: Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Creator	Chang, Ming-Fu Chen, I-Yin Ichinohe, Takeshi Moriyama, Miyu Lee, Heung Fujimoto, Yoshikazu
Source	Medline; PMC
abstract	Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate IL-1β secretion following activation of the NLRP3 inflammasome. However, the mechanism by which severe acute respiratory syndrome coronavirus (SARS-CoV) activates the NLRP3 inflammasome remains unknown. Here, we provide direct evidence that SARS-CoV 3a protein activates the NLRP3 inflammasome in lipopolysaccharide-primed macrophages. SARS-CoV 3a was sufficient to cause the NLRP3 inflammasome activation. The ion channel activity of the 3a protein was essential for 3a-mediated IL-1β secretion. While cells uninfected or infected with a lentivirus expressing a 3a protein defective in ion channel activity expressed NLRP3 uniformly throughout the cytoplasm, NLRP3 was redistributed to the perinuclear space in cells infected with a lentivirus expressing the 3a protein. K(+) efflux and mitochondrial reactive oxygen species were important for SARS-CoV 3a-induced NLRP3 inflammasome activation. These results highlight the importance of viroporins, transmembrane pore-forming viral proteins, in virus-induced NLRP3 inflammasome activation.
has issue date	2019-01-29(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.00050
bibo:pmid	30761102
has license	cc-by
sha1sum (hex)	f02d0c1e8b0109648e578662dc250abe349a033c
schema:url	https://doi.org/10.3389/fmicb.2019.00050
resource representing a document's title	Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
has PubMed Central identifier	PMC6361828
has PubMed identifier	30761102
schema:publication	Front Microbiol
resource representing a document's body	covid:f02d0c1e8b0109648e578662dc250abe349a033c#body_text
is schema:about of	named entity 'IL-1β' named entity 'Nod-like receptor' named entity 'provide' named entity 'remains' named entity 'SUFFICIENT' named entity 'VIRUS' named entity 'DEFECTIVE' covid:arg/f02d0c1e8b0109648e578662dc250abe349a033c named entity 'INTERLEUKIN 1 BETA' named entity 'THESE' named entity 'EXPRESSED' named entity 'VIROPORIN' named entity 'NOD-LIKE RECEPTOR' named entity 'CONTAINING' named entity 'ACTIVATION' named entity 'CYTOPLASM' named entity 'LENTIVIRUS' named entity 'PROVIDE' named entity 'TRANSMEMBRANE' named entity 'PROTEIN' named entity 'PROTEINS' named entity 'LIPOPOLYSACCHARIDE' named entity 'RESULTS' named entity 'REACTIVE OXYGEN SPECIES' named entity 'SECRETION' named entity 'UNKNOWN' named entity 'PORE' named entity 'THE NLRP3 INFLAMMASOME' named entity 'PERINUCLEAR SPACE' named entity 'ENCEPHALOMYOCARDITIS VIRUS' named entity 'STIMULATE' named entity 'MECHANISM' named entity 'ACTIVATES' named entity 'SARS-COV' named entity 'ACTIVATES' named entity 'PYRIN DOMAIN' named entity 'FOLLOWING' named entity 'MITOCHONDRIAL' named entity 'NLRP3' named entity 'IL-18' named entity 'CAUSE' named entity 'CELLS' named entity 'DIRECT' named entity 'HERE' named entity 'NLRP3 INFLAMMASOME ACTIVATION' named entity 'INFLUENZA VIRUS' named entity 'MACROPHAGES' named entity 'PROTEIN ' named entity 'FORMING' named entity 'UNINFECTED' named entity 'INFECTED' named entity 'THE NLRP3 INFLAMMASOME' named entity 'IL-1' named entity 'PRIMED' named entity 'VIRAL PROTEINS' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'IMPORTANT' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ION CHANNEL ACTIVITY' named entity 'PREVIOUSLY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ESSENTIAL' named entity 'MEDIATED' named entity 'EVIDENCE' named entity 'EFFLUX' named entity 'FAMILY' named entity 'INDUCED' named entity 'efflux' named entity 'family' named entity 'mechanism' named entity 'highlight' named entity 'SARS-CoV' named entity 'activation' named entity 'influenza' named entity 'stimulate' named entity 'protein'

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