About: Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.

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About: Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
Creator	Zhou, Jing Grubaugh, Nathan Alpert, Tara Fauver, Joseph Ko, Albert Vogels, Chantal Wilen, Craig Wyllie, Anne Barakat, Lydia Barakat, Shelli Bermejo, Santos Casanovas-Massana, Arnau Charles, Dela Chiarella, Jennifer Cruz, Charles Cruz, Craig Farhadian, Shelli Farhadian, Fournier, John Geng, Bertie Glick, Laura Grubaugh, Serena Ko, Sean Mackay, Nathan Mackay, Sean Odio, Camila Paczkowski, Patrick Spudich, Lydia Steinle, Matthew Thomas, Jared Turcotte, Cynthia Vijayakumar, Pavithra Wilen, Albert
Source	Medline; PMC
abstract	BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. CONCLUSION: Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-28583/v1
bibo:pmid	32702723
has license	cc-by
sha1sum (hex)	f0016f614b8c3306d1d685c90028a5d3e57d408c
schema:url	https://doi.org/10.21203/rs.3.rs-28583/v1
resource representing a document's title	Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
has PubMed Central identifier	PMC7336693
has PubMed identifier	32702723
schema:publication	Res Sq
resource representing a document's body	covid:f0016f614b8c3306d1d685c90028a5d3e57d408c#body_text
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