About: GSK983: A novel compound with broad-spectrum antiviral activity

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About: GSK983: A novel compound with broad-spectrum antiviral activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	GSK983: A novel compound with broad-spectrum antiviral activity
Creator	Zhang, Qin Brown, Kevin Biron, Karen Coffield, Neil Gartland, Margaret Gudmundsson, Kristjan Harvey, Robert Lawrence, Wendell Leary, Jeffry Moniri, Kelly Selleseth, Dean Sethna, Phiroze Singer, Sara Strum, Jay Talarico, Christine Walton, Leslie Romines, Karen
Source	Elsevier; Medline; PMC
abstract	Abstract GSK983, a novel tetrahydrocarbazole, inhibits the replication of a variety of unrelated viruses in vitro with EC50 values of 5–20nM. Both replication of the adenovirus Ad-5 and the polyoma virus SV-40, and episomal maintenance of human papillomaviruses (HPV) and Epstein-Barr virus (EBV) are susceptible to GSK983. The compound does not inhibit all viruses; herpes simplex virus (HSV-1), human immunodeficiency virus (HIV), and lytic replication of EBV were not susceptible at concentrations below 1μM. GSK983 does inhibit the growth of cell lines immortalized by HTLV-1, EBV, HPV, SV40 and Ad-5, with EC50 values in the range of 10–40nM. Depending on the cell line, the compound induces either apoptosis or cytostasis at concentrations over 20nM. GSK983 also inhibits cell lines immortalized by non-viral mechanisms, but has little effect on primary cells. The CC50 values for keratinocytes, fibroblasts, lymphocytes, endothelial, and bone marrow progenitor cells are all above 10μM. The pattern of inhibition, which includes diverse viruses as well as growth of immortalized cells of varied origins, suggests the target is a host cell protein, rather than a viral protein. Preliminary mechanism studies indicate that GSK983 acts by inducing a subset of interferon-stimulated genes.
has issue date	2009-04-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2008.12.015
bibo:pmid	19187793
has license	els-covid
sha1sum (hex)	efd2047275cacda42f51809c00ad61c23bef7e96
schema:url	https://doi.org/10.1016/j.antiviral.2008.12.015
resource representing a document's title	GSK983: A novel compound with broad-spectrum antiviral activity
has PubMed Central identifier	PMC7114156
has PubMed identifier	19187793
schema:publication	Antiviral Research
resource representing a document's body	covid:efd2047275cacda42f51809c00ad61c23bef7e96#body_text
is schema:about of	named entity 'studies' named entity 'human immunodeficiency virus (HIV)' named entity 'inhibit' named entity 'HPV' named entity 'compound' named entity 'broad-spectrum' named entity 'ANTIVIRAL ACTIVITY' named entity 'BROAD' named entity 'VIRAL PROTEIN' named entity 'EPSTEIN-BARR VIRUS' named entity 'MECHANISM' named entity 'INCLUDES' named entity 'PROTEIN' named entity 'LYMPHOCYTES' named entity 'REPLICATION' named entity 'LYTIC' named entity 'VIRUSES' named entity 'BONE MARROW' named entity 'UNRELATED' named entity 'KERATINOCYTES' named entity 'PRIMARY CELLS' named entity 'NOVEL' named entity 'MAINTENANCE' named entity 'COMPOUND' named entity 'HUMAN PAPILLOMAVIRUSES' named entity 'IN VITRO' named entity 'VALUES' named entity 'CELL LINES' named entity 'GSK983' named entity 'SPECTRUM' named entity 'GENES' named entity 'ACTS' named entity 'STUDIES' named entity 'ORIGINS' named entity 'NOVEL' named entity 'SUBSET' named entity 'S T' named entity 'TARGET' named entity 'HPV' named entity 'PATTERN' named entity 'GSK983' named entity 'NON-' named entity 'RATHER' named entity 'PROGENITOR CELLS' named entity 'STIMULATED' named entity 'LITTLE' named entity 'RANGE' named entity 'THE CELL' named entity 'DOES NOT' named entity 'HOST CELL' named entity 'AD-5' named entity 'EITHER' named entity 'APOPTOSIS' named entity 'HTLV-1' named entity 'SV40' named entity 'VIRAL' named entity 'IS A' named entity 'CONCENTRATIONS' named entity 'INTERFERON' named entity 'EFFECT' named entity 'VARIETY' named entity 'BUT' named entity 'SUSCEPTIBLE' named entity 'PRELIMINARY' named entity 'FIBROBLASTS'

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