About: Yeast for virus research

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Yeast for virus research Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Yeast for virus research
Creator	Zhao, Richard
Source	Medline; PMC
abstract	Budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe) are two popular model organisms for virus research. They are natural hosts for viruses as they carry their own indigenous viruses. Both yeasts have been used for studies of plant, animal and human viruses. Many positive sense (+) RNA viruses and some DNA viruses replicate with various levels in yeasts, thus allowing study of those viral activities during viral life cycle. Yeasts are single cell eukaryotic organisms. Hence, many of the fundamental cellular functions such as cell cycle regulation or programed cell death are highly conserved from yeasts to higher eukaryotes. Therefore, they are particularly suited to study the impact of those viral activities on related cellular activities during virus-host interactions. Yeasts present many unique advantages in virus research over high eukaryotes. Yeast cells are easy to maintain in the laboratory with relative short doubling time. They are non-biohazardous, genetically amendable with small genomes that permit genome-wide analysis of virologic and cellular functions. In this review, similarities and differences of these two yeasts are described. Studies of virologic activities such as viral translation, viral replication and genome-wide study of virus-cell interactions in yeasts are highlighted. Impacts of viral proteins on basic cellular functions such as cell cycle regulation and programed cell death are discussed. Potential applications of using yeasts as hosts to carry out functional analysis of small viral genome and to develop high throughput drug screening platform for the discovery of antiviral drugs are presented.
has issue date	2017-09-18(xsd:dateTime)
bibo:doi	10.15698/mic2017.10.592
bibo:pmid	29082230
has license	cc-by
sha1sum (hex)	efb09a669665f5e0e097c2d5e94c499a6e43bd9e
schema:url	https://doi.org/10.15698/mic2017.10.592
resource representing a document's title	Yeast for virus research
has PubMed Central identifier	PMC5657823
has PubMed identifier	29082230
schema:publication	Microbial cell
resource representing a document's body	covid:efb09a669665f5e0e097c2d5e94c499a6e43bd9e#body_text
is schema:about of	named entity 'fission yeast' named entity 'Yeasts' named entity 'carry' named entity 'yeasts' named entity 'cell cycle' named entity 'VIRUS' named entity 'EUKARYOTES' named entity 'HAVE' named entity 'CELL' named entity 'THESE' named entity 'RESEARCH' named entity 'VIRAL LIFE CYCLE' named entity 'BUDDING YEAST' named entity 'SENSE' named entity 'DRUG SCREENING' named entity 'REPLICATE' named entity 'YEAST CELLS' named entity 'NATURAL' named entity 'ACTIVITIES' named entity 'HIGH THROUGHPUT' named entity 'EUKARYOTIC' named entity 'PERMIT' named entity 'DNA VIRUSES' named entity 'THEIR' named entity 'HOSTS' named entity 'VARIOUS' named entity 'GENOMES' named entity 'LABORATORY' named entity 'BASIC' named entity 'VIRAL REPLICATION' named entity 'RELATED' named entity 'SHORT' named entity 'SMALL' named entity 'VIRAL PROTEINS' named entity 'VIROLOGIC' named entity 'IMPACT' named entity 'VIRUS' named entity 'VIRAL GENOME' named entity 'UNIQUE' named entity 'CONSERVED' named entity 'ORGANISMS' named entity 'VIRAL' named entity 'ANIMAL' named entity 'POSITIVE' named entity 'APPLICATIONS' named entity 'CARRY' named entity 'RELATIVE' named entity 'CELLULAR' named entity 'GENOME-WIDE ANALYSIS' named entity 'POTENTIAL' named entity 'CELL DEATH' named entity 'REVIEW' named entity 'PRESENT' named entity 'INDIGENOUS' named entity 'INTERACTIONS' named entity 'YEAST' named entity 'WIDE' named entity 'GENOME' named entity 'RESEARCH' named entity 'SINGLE CELL' named entity 'HIGHLY' named entity 'CELL CYCLE REGULATION' named entity 'HIGH' named entity 'PLATFORM' named entity 'STUDY' named entity 'STUDIES' named entity 'DISCOVERY' named entity 'DOUBLING TIME' named entity 'FISSION YEAST' named entity 'EASY' named entity 'LEVELS' named entity 'YEASTS' named entity 'USING' named entity 'YEASTS ' named entity 'ANTIVIRAL DRUGS' named entity 'MODEL ORGANISMS' named entity 'PLANT' named entity 'VIRUSES' named entity 'TO MAINTAIN' named entity 'HOST' named entity 'FUNCTIONAL ANALYSIS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software