About: Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH
Creator	Liu, Jia Yang, Yang Wang, Kai Huang, Shilei Song, Zhenhui Xie, Luyi Yang, Zhou Yuan, Peng Ran, Lin Song, Han
Source	Medline; PMC
abstract	Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are similar coronaviruses, causing diseases characterized by vomiting, diarrhea, and death from severe dehydration in piglets. Thus, they have caused huge losses to the swine-breeding industry worldwide. Nowadays, they are easily transmitted among the continents via vehicles, equipment, and cargo. Both viruses establish an infection in porcine enterocytes in the small intestine, and their spike (S) proteins play a key role in the virus-cell binding process under unfavorable conditions when the intestine with a low pH is filled with a thick layer of mucus and proteases. Sialic acid, proteases, and low pH are three main inducers of coronavirus infection. However, the details of how sialic acid and low pH affect virus binding to the host cell are not determined, and the functions of the proteases are unknown. This review emphasizes the role of three factors in the invasion of TGEV and PEDV into porcine enterocytes and offers more insights into Alphacoronavirus infection in the intestinal environment.
has issue date	2018-09-03(xsd:dateTime)
bibo:doi	10.1159/000492424
bibo:pmid	30176660
has license	no-cc
sha1sum (hex)	ef981f53da4aeef3dde4e9741eff999a0a46c5c1
schema:url	https://doi.org/10.1159/000492424
resource representing a document's title	Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH
has PubMed Central identifier	PMC7179561
has PubMed identifier	30176660
schema:publication	Intervirology
resource representing a document's body	covid:ef981f53da4aeef3dde4e9741eff999a0a46c5c1#body_text
is schema:about of	named entity 'host' named entity 'environment' named entity 'Alphacoronavirus' named entity 'details' named entity 'vomiting' named entity 'emphasizes' named entity 'caused' named entity 'FILLED' named entity '28S' named entity 'HAVE' named entity 'CELL BINDING' named entity 'porcine' named entity 'severe' named entity 'inducers' named entity 'losses' named entity 'binding' named entity 'continents' named entity 'low pH' named entity 'low pH' named entity 'enterocytes' named entity 'diarrhea' named entity 'swine' named entity 'coronavirus infection' named entity 'TGEV' named entity 'Transmissible gastroenteritis virus' named entity 'Enterocytes' named entity 'Alphacoronavirus' named entity 'Infection' named entity 'Inducers' named entity 'host cells' named entity 'glycosylated' named entity 'protease' named entity 'papain' named entity 'membrane fusion' named entity 'endosomal compartment' named entity 'viral particles' named entity 'TGEV' named entity 'cell surface receptor' named entity 'diarrhea' named entity 'PEDV' named entity 'receptor recognition' named entity 'RNAs' named entity 'causative agent' named entity 'β-CoV' named entity 'cellular receptors' named entity 'host cells' named entity 'infection' named entity 'polyprotein' named entity 'PEDV' named entity 'RBD' named entity 'CTD' named entity 'replicase' named entity 'protein' named entity 'porcine' named entity 'PEDV' named entity 'proteases' named entity 'β-strands' named entity 'MSPL' named entity 'socalled' named entity 'proteases' named entity 'IFN' named entity 'gene' named entity 'virions' named entity 'pig' named entity 'TGEV' named entity 'cell surface receptors' named entity 'PEDV' named entity 'infection' named entity 'HCoV-229E' named entity 'infection' named entity 'porcine' named entity 'coronavirus'

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