About: The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges
Creator	Lau, Chotirmall, Goh, Thng Kenny, J Micheál, Tiew Nur A'tikah Binte, Mac Sanjay, H Xian, Mohamed Yee, Pei
Source	PMC
abstract	Fungal disease is an increasingly recognised global clinical challenge associated with high mortality. Early diagnosis of fungal infection remains problematic due to the poor sensitivity and specificity of current diagnostic modalities. Advances in sequencing technologies hold promise in addressing these shortcomings and for improved fungal detection and identification. To translate such emerging approaches into mainstream clinical care will require refinement of current sequencing and analytical platforms, ensuring standardisation and consistency through robust clinical benchmarking and its validation across a range of patient populations. In this state-of-the-art review, we discuss current diagnostic and therapeutic challenges associated with fungal disease and provide key examples where the application of sequencing technologies has potential diagnostic application in assessing the human ‘mycobiome’. We assess how ready access to fungal sequencing may be exploited in broadening our insight into host–fungal interaction, providing scope for clinical diagnostics and the translation of emerging mycobiome research into clinical practice.
has issue date	2020-01-01(xsd:dateTime)
bibo:doi	10.1007/s11046-019-00413-z
bibo:pmid	31894501
has license	no-cc
sha1sum (hex)	ef95f4bf71dcac170b9e4a2c4ea65bef7a85b0b8
schema:url	https://doi.org/10.1007/s11046-019-00413-z
resource representing a document's title	The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges
has PubMed Central identifier	PMC7223441
has PubMed identifier	31894501
schema:publication	Mycopathologia
resource representing a document's body	covid:ef95f4bf71dcac170b9e4a2c4ea65bef7a85b0b8#body_text
is schema:about of	named entity 'promise' named entity 'emerging' named entity 'populations' named entity 'refinement' named entity 'mortality' named entity 'sensitivity' named entity 'CLINICAL CARE' named entity 'KEY' named entity 'PROBLEMATIC' named entity 'THERAPEUTIC' named entity 'DETECTION' named entity 'HOLD' named entity 'FUNGAL INFECTION' named entity 'application' named entity 'addressing' named entity 'translation' named entity 'application' named entity 'global' named entity 'assess' named entity 'therapeutic' named entity 'benchmarking' named entity 'scope' named entity 'Methodologies' named entity 'sequencing technologies' named entity 'antibiotics' named entity 'Donovan' named entity 'precision medicine' named entity 'dysbiosis' named entity 'microbes' named entity 'genome' named entity 'Acremonium' named entity 'non-coding DNA' named entity 'antifungal drug' named entity 'fungi' named entity 'amplicon sequencing' named entity 'fungi' named entity 'Rhodotorula' named entity 'fungi' named entity 'haematological malignancy' named entity 'ITS1' named entity 'fungal disease' named entity 'antibacterial' named entity 'Candida' named entity 'antifungal' named entity 'homoeostasis' named entity 'bacterial microbiome' named entity '28S rRNA' named entity 'microbes' named entity 'human gut' named entity 'empirical treatment' named entity 'bronchiectasis' named entity 'azoles' named entity 'human health' named entity 'Endemic' named entity 'microbiomes' named entity 'microbial' named entity 'yeast' named entity 'Cladosporium' named entity 'Drug toxicity' named entity 'therapeutic approaches' named entity 'life-threatening disease' named entity 'Malassezia' named entity 'Candida' named entity 'anatomical' named entity 'microbiomes' named entity 'candidiasis' named entity 'fungi' named entity 'pathogenesis' named entity 'S. cerevisiae' named entity 'allergies' named entity 'internal transcribed spacer' named entity 'M. sympodialis' named entity 'mycobiome'

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