About: Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia
Creator	Lin, Chih-Yin Yao, Chun-An
Source	Medline; PMC; WHO
abstract	The outbreak of coronavirus disease 2019 (COVID-19) pandemic has already caused a huge burden to the global healthcare system, with the death toll reached tens of thousands. Although some antiviral agents were identified and used to inhibit viral replication, the management of cytokine storm is also a critical issue. In this article, we reviewed the literature on drug candidates for severe acute respiratory syndrome (SARS-CoV-1) and provided a brief overview of a class of drugs that exert antiviral and anti-inflammatory effects. These molecules mitigated inflammatory cytokine cascades induced by viral infections via Nrf2 activating capacity and might have additional anti-fibrotic and anti-remodeling properties. Besides, their effects on the regulation of scavenger receptors expression by macrophages may offer some benefits to the pulmonary antibacterial defense system after viral infection. The potential roles of these agents assessed on the basis of the pathophysiology of viral pneumonia and acute respiratory distress syndrome were also discussed. Further research is needed to ascertain whether Nrf2 activators are useful in the management of viral pneumonia.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.2147/idr.s256773
bibo:pmid	32606823
has license	cc-by-nc
sha1sum (hex)	ef50603d1087c2d5e93ee624ad7ff25f9d27a98c
schema:url	https://doi.org/10.2147/idr.s256773
resource representing a document's title	Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia
has PubMed Central identifier	PMC7295331
has PubMed identifier	32606823
schema:publication	Infect Drug Resist
resource representing a document's body	covid:ef50603d1087c2d5e93ee624ad7ff25f9d27a98c#body_text
is schema:about of	named entity 'activating' named entity 'expression' named entity 'tens' named entity 'management' named entity 'potential' named entity 'pandemic' named entity 'macrophages' named entity 'ADDITIONAL' named entity 'ANTIVIRAL' named entity 'USED' named entity 'CORONAVIRUS DISEASE 2019' named entity 'BRIEF' named entity 'PATHOPHYSIOLOGY' named entity 'USEFUL' named entity 'ACTIVATING' named entity 'VIRAL PNEUMONIA' named entity 'VIRAL INFECTIONS' named entity 'RESEARCH' named entity 'REVIEWED' named entity 'GLOBAL' covid:arg/ef50603d1087c2d5e93ee624ad7ff25f9d27a98c named entity 'coronavirus disease 2019' named entity 'burden' named entity 'capacity' named entity 'viral pneumonia' named entity 'effects' named entity 'literature' named entity 'defense' named entity 'Potential' named entity 'coronavirus disease 2019' named entity 'viral infections' named entity 'Nrf2' named entity 'viral pneumonia' named entity 'chemoprevention' named entity 'curcumin' named entity 'Nrf2' named entity 'curcumin' named entity 'pulmonary fibrosis' named entity 'mouse model' named entity 'epithelial cells' named entity 'RNA viruses' named entity 'curcumin' named entity 'viral pneumonia' named entity 'triterpenes' named entity 'phytochemicals' named entity '31, 33' named entity 'Nrf2' named entity 'clinical practice' named entity 'anti-inflammatory' named entity 'naturally occurring' named entity 'lung tissue' named entity 'terpenes' named entity 'Nrf2' named entity 'safety profile' named entity 'Curcumin' named entity 'curcumin' named entity 'inhalation' named entity 'curcumin' named entity 'bardoxolone methyl' named entity 'HEK 293' named entity 'Nrf2' named entity 'cytokines' named entity 'influenza A virus' named entity 'bardoxolone methyl' named entity 'lipopolysaccharide' named entity 'curcumin' named entity 'tetracycline' named entity 'inflammation' named entity 'COVID' named entity 'bacterial pneumonia' named entity 'IL-1β' named entity 'antioxidant' named entity 'minocycline' named entity 'oral bioavailability' named entity 'inflammatory cells' named entity 'COVID' named entity 'TGF-β' named entity 'influenza virus' named entity 'airway' named entity 'vaccination'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software