About: Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial

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About: Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial
Creator	Aly Id, Sharif Champagne, John Feldmann, Hillary Lehenbauer, Terry Williams, Deniece
Source	Medline; PMC
abstract	The objective of this clinical trial was to evaluate the effectiveness of zinc supplementation on diarrhea and average daily weight gain (ADG) in pre-weaned dairy calves. A total of 1,482 healthy Holstein heifer and bull calves from a large California dairy were enrolled at 24 to 48 hours of age until hutch exit at approximately 90 days of age. Calves were block-randomized by time to one of three treatments: 1) placebo, 2) zinc methionine (ZM), or 3) zinc sulfate (ZS) administered in milk once daily for 14 days. Serum total protein at enrollment and body weight at birth, treatment end, and hutch exit were measured. Fecal consistency was assessed daily for 28 days post-enrollment. For a random sample of 127 calves, serum zinc concentrations before and after treatment and a fecal antigen ELISA at diarrhea start and resolution for Escherichia coli K99, rotavirus, coronavirus, and Cryptosporidium parvum were performed. Linear regression showed that ZM-treated bull calves had 22 g increased ADG compared to placebo-treated bulls (P = 0.042). ZM-treated heifers had 9 g decreased ADG compared to placebo-treated heifers (P = 0.037), after adjusting for average birth weight. Sex-stratified models showed that high birth weight heifers treated with ZM gained more than placebo-treated heifers of the same birth weight, which suggests a dose-response effect rather than a true sex-specific effect of ZM on ADG. Cox regression showed that ZM and ZS-treated calves had a 14.7% (P = 0.015) and 13.9% (P = 0.022) reduced hazard of diarrhea, respectively, compared to placebo-treated calves. Calves supplemented for at least the first five days of diarrhea with ZM and ZS had a 21.4% (P = 0.027) and 13.0% (P = 0.040) increased hazard of cure from diarrhea, respectively, compared to placebo-treated calves. Logistic regression showed that the odds of microbiological cure at diarrhea resolution for rotavirus, C. parvum, or any single fecal pathogen was not different between treatment groups. Zinc supplementation delayed diarrhea and expedited diarrhea recovery in pre-weaned calves. Additionally, zinc improved weight gain differentially in bulls compared to heifers, indicating a research need for sex-specific dosing.
has issue date	2019-07-10(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0219321
bibo:pmid	31291305
has license	cc-by
sha1sum (hex)	ef20a0cd67ce018cf061f154bd8be9d0e58d0f23
schema:url	https://doi.org/10.1371/journal.pone.0219321
resource representing a document's title	Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial
has PubMed Central identifier	PMC6619766
has PubMed identifier	31291305
schema:publication	PLoS One
resource representing a document's body	covid:ef20a0cd67ce018cf061f154bd8be9d0e58d0f23#body_text
is schema:about of	named entity 'assessed' named entity 'hutch' named entity 'Linear regression' named entity 'hutch' named entity 'Cox regression' named entity 'recovery' named entity 'cure' named entity 'diarrhea' covid:arg/ef20a0cd67ce018cf061f154bd8be9d0e58d0f23 named entity 'C. parvum' named entity 'calves' named entity 'compared' named entity 'improved' named entity 'diarrhea' named entity 'total' named entity 'odds' named entity 'Holstein' named entity 'calves' named entity 'days' named entity 'birth weight' named entity 'random sample' named entity 'weight gain' named entity 'days' named entity 'evaluate' named entity 'compared' named entity 'pathogen' named entity 'California' named entity 'age' named entity 'reduced' named entity 'For' named entity 'Logistic regression' named entity 'California' named entity 'diarrhea' named entity 'placebo' named entity 'zinc sulfate' named entity '28 days' named entity 'placebo' named entity 'zinc' named entity 'microbiological' named entity 'weight gain' named entity 'weight at birth' named entity 'diarrhea' named entity 'dairy calves' named entity 'placebo-controlled clinical trial' named entity 'zinc supplementation' named entity 'compared' named entity 'centrifuged' named entity 'clinical trial' named entity 'body weight' named entity 'zinc supplementation' named entity 'bovine' named entity 'pasteurized' named entity 'diarrhea' named entity 'zinc' named entity 'placebo' named entity 'plasma-optical emission spectroscopy' named entity 'zinc' named entity 'diarrhea' named entity 'dairy calves' named entity 'zinc' named entity 'diarrhea' named entity 'level of significance' named entity 'placebo' named entity 'inductively coupled plasma mass spectrometry' named entity 'Fisher Scientific' named entity 'Serum' named entity 'diarrhea' named entity 'trace element' named entity 'serum total protein' named entity 'pathogens' named entity 'C. parvum' named entity 'dairy calves' named entity 'oocysts' named entity 'oocyst' named entity 'E. coli' named entity 'diarrhea' named entity 'Cryptosporidium parvum'

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