About: Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19

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About: Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19
Creator	Xu, Jin Jia, Ran Liu, • Wang, • Chang, Hailing Ge, Yanling Liang, • Hao Zhou, • Tian, • Zeng, •
Source	Medline; PMC
abstract	Children with Coronavirus Disease 2019 (COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. Therefore we initiated this study to figure out the features of immune response in children with COVID-19. Sera and whole blood cells from 19 children with COVID-19 during different phases after disease onset were collected. The cytokine concentrations, SARS-CoV-2 S-RBD or N-specific antibodies and T cell immune responses were detected respectively. In children with COVID-19, only 3 of 12 cytokines were increased in acute sera, including interferon (IFN)-γ-induced protein 10 (IP10), interleukin (IL)-10 and IL-16. We observed an increase in T helper (Th)-2 cells and a suppression in regulatory T cells (Treg) in patients during acute phase, but no significant response was found in the IFN-γ-producing or tumor necrosis factor (TNF)-α-producing CD8(+ )T cells in patients. S-RBD and N IgM showed an early induction, while S-RBD and N IgG were prominently induced later in convalescent phase. Potent S-RBD IgA response was observed but N IgA seemed to be inconspicuous. Children with COVID-19 displayed an immunophenotype that is less inflammatory than adults, including unremarkable cytokine elevation, moderate CD4(+) T cell response and inactive CD8(+) T cell response, but their humoral immunity against SARS-CoV-2 were as strong as adults. Our finding presented immunological characteristics of children with COVID-19 and might give some clues as to why children develop less severe disease than adults.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1007/s12250-020-00265-8
bibo:pmid	32699972
has license	no-cc
sha1sum (hex)	ef024f02ba0d8cb06a27085661afd70975dd294a
schema:url	https://doi.org/10.1007/s12250-020-00265-8
resource representing a document's title	Mild Cytokine Elevation, Moderate CD4(+) T Cell Response and Abundant Antibody Production in Children with COVID-19
has PubMed Central identifier	PMC7373847
has PubMed identifier	32699972
schema:publication	Virol Sin
resource representing a document's body	covid:ef024f02ba0d8cb06a27085661afd70975dd294a#body_text
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