About: Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults
Creator	Gudmundsson, Anders Löndahl, Jakob Nicklasson, Hanna Rissler, Jenny Swietlicki, Erik
Source	PMC
abstract	BACKGROUND: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood. METHOD: In this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15–5000 nm and includes 67 subjects aged 7–70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition. RESULTS: A large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry). CONCLUSIONS: To understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12989-017-0190-8) contains supplementary material, which is available to authorized users.
has issue date	2017-04-08(xsd:dateTime)
bibo:doi	10.1186/s12989-017-0190-8
bibo:pmid	28388961
has license	cc-by
sha1sum (hex)	eeeb522c3d685b3b771700a5a5ba4ef1237c19f5
schema:url	https://doi.org/10.1186/s12989-017-0190-8
resource representing a document's title	Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults
has PubMed Central identifier	PMC5385003
has PubMed identifier	28388961
schema:publication	Part Fibre Toxicol
resource representing a document's body	covid:eeeb522c3d685b3b771700a5a5ba4ef1237c19f5#body_text
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