About: Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus

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About: Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
Creator	Liao, Ying Huang, Mei Liu, Xiang Wang, Xiaoxing Tam, James
Source	Elsevier; Medline; PMC
abstract	Induction of pro-inflammatory response is a crucial cellular process that detects and controls the invading viruses at early stages of the infection. Along with other innate immunity, this nonspecific response would either clear the invading viruses or allow the adaptive immune system to establish an effective antiviral response at late stages of the infection. The objective of this study was to characterize cellular mechanisms exploited by coronavirus infectious bronchitis virus (IBV) to regulate the induction of two pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, at the transcriptional level. The results showed that IBV infection of cultured human and animal cells activated the p38 mitogen-activated protein kinase (MAPK) pathway and induced the expression of IL-6 and IL-8. Meanwhile, IBV has developed a strategy to counteract the induction of IL-6 and IL-8 by inducing the expression of dual-specificity phosphatase 1 (DUSP1), a negative regulator of the p38 MAPK, in order to limit the production of an excessive amount of IL-6 and IL-8 in the infected cells. As activation of the p38 MAPK pathway and induction of IL-6 and IL-8 may have multiple pathogenic effects on the whole host as well as on individual infected cells, regulation of the p38 MAPK and DUSP1 feedback loop by IBV may modulate the pathogenesis of the virus.
has issue date	2011-11-25(xsd:dateTime)
bibo:doi	10.1016/j.virol.2011.09.003
bibo:pmid	21959016
has license	no-cc
sha1sum (hex)	eed5a0cc4fc05708047a6bd4627aac5cf5fdc59f
schema:url	https://doi.org/10.1016/j.virol.2011.09.003
resource representing a document's title	Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
has PubMed Central identifier	PMC7111953
has PubMed identifier	21959016
schema:publication	Virology
resource representing a document's body	covid:eed5a0cc4fc05708047a6bd4627aac5cf5fdc59f#body_text
is schema:about of	named entity 'viruses' named entity 'infection' named entity 'modulate' named entity 'coronavirus' named entity 'exploited' named entity 'IL-6' named entity 'modulates' named entity 'induction' covid:arg/eed5a0cc4fc05708047a6bd4627aac5cf5fdc59f named entity 'transcriptional' named entity 'mechanisms' named entity 'feedback loop' named entity 'mitogen-activated protein kinase' named entity 'MAPK' named entity 'response' named entity 'IBV' named entity 'p38 MAPK' named entity 'induction' named entity 'IL-8' named entity 'interleukin' named entity 'infection' named entity 'IL-8' named entity 'infection' named entity 'IL-8' named entity 'pro-inflammatory cytokines' named entity 'antiviral' named entity 'negative regulator' named entity 'p38 MAPK' named entity 'animal cells' named entity 'IL-6' named entity 'infection' named entity 'p38 MAPK' named entity 'interleukin 6' named entity 'expression' named entity 'Vero cells' named entity 'IBV' named entity 'African green monkey' named entity 'p38 MAPK' named entity 'IBV' named entity 'FBS' named entity 'H1299' named entity 'p38 MAPK pathway' named entity 'infection' named entity 'IL-6' named entity 'IL-6' named entity 'IBV' named entity 'IBV' named entity 'interferon' named entity 'infection' named entity 'programmed cell death' named entity 'Cell Signaling Technology' named entity 'infection' named entity 'IBV' named entity 'IBV' named entity 'liver tumor' named entity 'p38 MAPK' named entity 'Western blot' named entity 'Affymetrix' named entity 'caspase-dependent apoptosis' named entity 'IL-8' named entity 'p38 MAPK' named entity 'RNA' named entity 'DNA viruses' named entity 'DUSP1' named entity 'IL-6' named entity '1.2' named entity 'isoforms' named entity 'IRF1' named entity 'p38 MAPK' named entity 'IBV' named entity 'enhanced chemiluminescence' named entity 'transfection' named entity 'IBV' named entity 'plaque assay' named entity 'dsRNA' named entity 'IBV' named entity 'IL-6'

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