About: Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009

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About: Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009
Creator	Carrat, Fabrice Tortosa, Pablo Temmam, Sarah Salez, Nicolas Flahault, Antoine Dellagi, Koussay Pascalis, Hervé De Lamballerie, Xavier Boussaïd, Karim Favier, Francois Fianu, Adrian Filleul, Laurent Guernier, Vanina Jaffar-Banjee, Marie-Christine Lapidus, Nathanael Rollot, Olivier Gé Rardin, Patrick Nadè Ge Naty,
Source	Medline; PMC
abstract	BACKGROUND: To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season. METHODOLOGY/PRINCIPAL FINDINGS: A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20–59 years) and 73.3% in the elderly (≥60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive. CONCLUSIONS: Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses.
has issue date	2011-09-29(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0025738
bibo:pmid	21980532
has license	cc-by
sha1sum (hex)	ee6d70a53e3262cea6f85bd8b226f6b4c8b5f64b
schema:url	https://doi.org/10.1371/journal.pone.0025738
resource representing a document's title	Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009
has PubMed Central identifier	PMC3183080
has PubMed identifier	21980532
schema:publication	PLoS One
resource representing a document's body	covid:ee6d70a53e3262cea6f85bd8b226f6b4c8b5f64b#body_text
is schema:about of	named entity 'Background' named entity '2009' named entity 'Infection' covid:arg/ee6d70a53e3262cea6f85bd8b226f6b4c8b5f64b named entity 'influenza pandemic' named entity 'infection' named entity 'Reunion Island' named entity '2009' named entity 'rates of infection' named entity 'seroprevalence' named entity 'statistical analysis' named entity 'HIA' named entity 'community transmission' named entity 'Mexico' named entity 'Mauritius' named entity 'epidemic' named entity 'seasonal flu' named entity 'Antibodies' named entity 'influenza virus' named entity 'nasal swab' named entity 'virus' named entity 'herd immunity' named entity 'Institute of Research for Development' named entity 'gold standard test' named entity 'serum' named entity 'epidemic' named entity 'serosurvey' named entity 'titer' named entity 'Invitrogen' named entity 'qRT-PCR' named entity 'asymptomatic' named entity 'serum' named entity 'seroconversion' named entity 'seroprevalence' named entity 'herd immunity' named entity 'Reunion Island' named entity 'trypsin' named entity 'subclinical' named entity 'antibody response' named entity 'infection' named entity 'antibodies' named entity 'incubation' named entity 'HIA' named entity 'epidemic' named entity 'Hemagglutination inhibition assay' named entity 'sera' named entity 'morbidity' named entity 'virus' named entity 'seroconversion' named entity 'qRT-PCR' named entity 'HIA' named entity 'serum' named entity 'infection' named entity 'RT-PCR' named entity 'cumulative incidence' named entity 'PCR' named entity 'seroconversion' named entity 'HIA' named entity 'virus' named entity 'antibody' named entity 'men at work' named entity 'seroprevalence' named entity '2009 pandemic' named entity 'HIA'

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