About: Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state

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About: Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state
Creator	Stijnen, Theo Beenakker, Karel De Craen, Anton Ling, Carolina Maier, Andrea Meskers, G Westendorp, Rudi
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: There is growing recognition of the serious consequences of sarcopenia on the functionality and autonomy in old age. Recently, the age-related changes in several inflammatory mediators have been implicated in the pathogenesis of sarcopenia. The purposes of this systematic review were two-fold: (1) to describe the patterns of muscle strength loss with age in the general population, and (2) to quantify the loss of muscle strength in rheumatoid arthritis as representative for an underlying inflammatory state. Handgrip strength was used as a proxy for overall muscle strength. RESULTS: Results from 114 studies (involving 90,520 subjects) and 71 studies (involving 10,529 subjects) were combined in a meta-analysis for the general and rheumatoid arthritis population respectively and standardized at an equal sex distribution. For the general population we showed that between the ages of 25 years and 95 years mean handgrip strength declined from 45.5 kg to 23.2 kg for males and from 27.1 kg to 12.8 kg for females. We noted a steeper handgrip strength decline after 50 years of age (rate of 0.37 kg/year). In the rheumatoid arthritis population handgrip strength was not associated with chronological age between the ages of 35 years and 65 years and was as low as 20.2 kg in male and 15.1 in female. Rheumatoid arthritis disease duration was inversely associated with handgrip strength. CONCLUSIONS: This meta-analysis shows distinct patterns of age-related decrease of handgrip strength in the general population. Handgrip strength is strongly associated with the presence and duration of an inflammatory state as rheumatoid arthritis. The putative link between age-related inflammation and sarcopenia mandates further study as it represents a potential target for intervention to maintain functional independence in old age.
has issue date	2010-05-27(xsd:dateTime)
bibo:doi	10.1016/j.arr.2010.05.005
bibo:pmid	20553969
has license	no-cc
sha1sum (hex)	ee197c18999212ede96283c636088ae1ee232ea1
schema:url	https://doi.org/10.1016/j.arr.2010.05.005
resource representing a document's title	Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state
has PubMed Central identifier	PMC7105185
has PubMed identifier	20553969
schema:publication	Ageing Res Rev
resource representing a document's body	covid:ee197c18999212ede96283c636088ae1ee232ea1#body_text
is schema:about of	named entity 'STATE' named entity 'loss' named entity 'age' named entity 'meta-analysis' named entity 'general' covid:arg/ee197c18999212ede96283c636088ae1ee232ea1 named entity 'AGE' named entity 'AGES' named entity 'FUNCTIONALITY' named entity 'STRENGTH LOSS' named entity '0.37' named entity '114' named entity 'CONSEQUENCES' named entity 'MUSCLE STRENGTH' named entity 'ASSOCIATED WITH' named entity 'DECLINE' named entity 'FEMALE' named entity 'USED' named entity 'FEMALES' named entity 'SEX DISTRIBUTION' named entity 'MALES' named entity 'GENERAL POPULATION' named entity 'RESULTS' named entity 'AGE' named entity 'FOLD' named entity 'YEARS' named entity '282' named entity 'NOTED' named entity 'GENERAL POPULATION' named entity 'MUSCLE STRENGTH' named entity 'INFLAMMATORY' named entity 'REPRESENTATIVE' named entity 'STATE' named entity 'GROWING' named entity 'PROXY' named entity 'CHRONIC' named entity 'PATIENTS' named entity 'PATHOGENESIS' named entity 'DISEASE DURATION' named entity 'RELATED' named entity 'RECOGNITION' named entity 'PURPOSES' named entity 'LOSS OF' named entity 'MALE' named entity 'EQUAL' named entity 'STRENGTH LOSS' named entity 'PATTERNS' named entity 'TO DESCRIBE' named entity 'HANDGRIP' named entity 'GENERAL' named entity 'QUANTIFY' named entity 'INFLAMMATORY' named entity 'STUDIES' named entity 'PATTERNS' named entity 'OVERALL' named entity 'LOW' named entity 'RHEUMATOID ARTHRITIS' named entity '12.8' named entity 'CHANGES' named entity '20.2' named entity 'INFLAMMATORY MEDIATORS' named entity 'META-ANALYSIS' named entity 'HAVE' named entity 'SUBJECTS' named entity 'OLD AGE' named entity 'UNDERLYING' named entity 'MEAN' named entity 'CHRONOLOGICAL AGE' named entity 'COMBINED' named entity 'SARCOPENIA' named entity '90%' named entity '10%' named entity 'AUTONOMY' named entity 'SYSTEMATIC REVIEW' named entity 'RECENTLY'

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