About: Acute Olfactory Dysfunction—A Primary Presentation of COVID-19 Infection

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About: Acute Olfactory Dysfunction—A Primary Presentation of COVID-19 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute Olfactory Dysfunction—A Primary Presentation of COVID-19 Infection
Creator	Brookes, Gerald Brookes, Natalie Fairley, James Orl-Hns, Frcs Oxon, Ma
Source	Medline; PMC
abstract	COVID-19 is a zoonotic illness caused by a new strain of coronavirus and has recently been declared a pandemic by the World Health Organization, with an estimated fatality rate of 1% to 2%. Early identification and isolation of patients in the preliminary infective stage has been a mainstay of most governmental strategies in order to limit transmission. Four otherwise healthy patients presented to a specialist open access Ear, Nose & Throat Clinic in central London with acute total or subtotal loss of their sense of smell in a single one-week period, coinciding with rapid escalation of COVID-19 infection in the indigenous population. The diagnosis was confirmed by the validated University of Pennsylvania Smell Identification Test (UPSIT) in 3. Endoscopic examination and magnetic resonance imaging (2 cases) excluded a range of alternative potential pathological conditions. Covid-19 antibody testing carried out 6 to 8 weeks after the onset of nasal symptoms showed positive immunoglobulin G antibodies in 3 of the 4 patients. Acute severe anosmia is therefore almost certainly an unusual presenting local nasal feature of a COVID-19 viral infection. All 4 patients achieved significant partial olfactory recovery by one week after treatment with subjective ratings of 40% to 85% of normal (mean 60%) and complete olfaction recovery after 2 to 3 weeks in all 4 patients. The significance, possible pathogenesis, and public health implications are highlighted and discussed.
has issue date	2020-08-06(xsd:dateTime)
bibo:doi	10.1177/0145561320940119
bibo:pmid	32757995
has license	cc-by-nc
sha1sum (hex)	eddab369a24c2b1185dc22b16584beb86f1abe30
schema:url	https://doi.org/10.1177/0145561320940119
resource representing a document's title	Acute Olfactory Dysfunction—A Primary Presentation of COVID-19 Infection
has PubMed Central identifier	PMC7412078
has PubMed identifier	32757995
schema:publication	Ear Nose Throat J
resource representing a document's body	covid:eddab369a24c2b1185dc22b16584beb86f1abe30#body_text
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