About: Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats

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About: Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats
Creator	Ramasamy, Kandasamy Smee, Donald Alaghamandan, Hassan Revankar, Ganapathi
Source	Elsevier; Medline; PMC
abstract	Abstract A novel nucleoside analog, 8-chloro-7-deazaguanosine (8-Cl-7-dzGuo), was evaluated for anti-RNA virus activity in rodents in parallel with the related compound 7-deaza-7-thia-8-oxoguanosine (7-dzTOGuo). Half-daily intraperitoneal (i.p.) doses of each substance administered 24 and 18 h prior to i.p. virus challenge protected the majority of mice infected with banzi, encephalomyocarditis, San Angelo, and Semliki Forest viruses at doses of 25, 50 and 100 mg/kg/day. These compounds at 100 mg/kg/day also protected most suckling rats infected intranasally with rat coronavirus. However, no survival benefit was afforded to treated mice infected intranasally with vesicular stomatitis virus. 8-Cl-7-dzguo was orally active against Semliki Forest virus in mice at 200 and 400 mg/kg/day, whereas 7-dzTOGuo is reported to not be effective orally. In uninfected mice, the two compounds induced similar amounts of interferon following i.p. injections. Interferon was induced by oral treatments with 8-Cl-7-dzGuo but not with 7-dzTOGuo. Fifty percent acute lethal doses to uninfected mice treated i.p. in half-daily doses for one day with 7-deazaguanosine (7-dzGuo), 7-dzTOGuo, and 8-Cl-7-dzGuo were 400, 600 and > 1600 (no mortality at this dose) mg/kg/day, respectively. Daily, i.p. treatments for 14 days with these substances (100 mg/kg/day) showed 7-dzGuo as 100% lethal and the other two substances at not toxic. By virtue of reduced toxicity and oral bioavailability, 8-Cl-7-dzGuo appears to have the greatest clinical potential as an interferon-inducing antiviral agent.
has issue date	1995-03-31(xsd:dateTime)
bibo:doi	10.1016/0166-3542(94)00084-l
bibo:pmid	7605116
has license	els-covid
sha1sum (hex)	edcc08f09cf5fe1bb0e866f7e2fdcbd8b0a07061
schema:url	https://doi.org/10.1016/0166-3542%2894%2900084-l
resource representing a document's title	Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats
has PubMed Central identifier	PMC7125532
has PubMed identifier	7605116
schema:publication	Antiviral Research
resource representing a document's body	covid:edcc08f09cf5fe1bb0e866f7e2fdcbd8b0a07061#body_text
is schema:about of	named entity 'REPORTED' named entity '100%' named entity 'ORAL BIOAVAILABILITY' named entity 'UNINFECTED' named entity 'ORALLY' named entity 'HAVE' named entity 'SURVIVAL' named entity 'PARALLEL' named entity '600' named entity 'TREATMENTS' named entity 'FIFTY' named entity 'THIA' named entity 'NOVEL' named entity 'DAYS' named entity '1600' named entity 'SEMLIKI FOREST VIRUS' named entity '287' named entity 'TOXICITY' named entity 'I.P.' named entity 'NUCLEOSIDE ANALOG' named entity 'SAN ANGELO' named entity '7-DEAZAGUANOSINE' named entity 'ADMINISTERED' named entity 'ACUTE' named entity 'substance' named entity 'survival' named entity 'i.p.' named entity 'mice' named entity 'mice' named entity 'virus' named entity 'Semliki' named entity 'TOXIC' named entity 'RATS' named entity 'EVALUATED' named entity 'PERCENT' named entity 'THESE' named entity 'VIRUS' named entity 'INDUCING' named entity 'INTERFERON ' named entity 'RNA VIRUS' named entity '8-CHLORO-7-DEAZAGUANOSINE' named entity 'ACTIVITY' named entity '400' named entity 'MICE' named entity 'SUBSTANCES' named entity 'RELATED' named entity 'PRIOR TO' named entity 'SIMILAR' named entity 'FOREST' named entity 'POTENTIAL' named entity 'ORAL' named entity 'FOLLOWING' named entity '28I' named entity '100' named entity 'REDUCED' named entity 'OF EACH' named entity 'RATS' named entity 'RNA VIRUS INFECTIONS' named entity 'MICE' named entity 'INDUCED' named entity 'BENEFIT' named entity 'BUT' named entity 'ONE DAY' named entity 'MAJORITY' named entity 'CLINICAL' named entity 'INTRAPERITONEAL' named entity 'TREATED' named entity 'HALF' named entity 'DAILY' named entity 'INJECTIONS' named entity 'DOSES' named entity 'DOSE' named entity 'VIRTUE' named entity 'SPECTRUM' named entity 'BROAD' named entity 'MORTALITY' named entity 'ACTIVITY' named entity 'SUBSTANCE'

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