About: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report

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About: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report
Creator	Mehler, Mark Ballaban-Gil, Karen Boro, Alexis Cherian, Koshi Correa, Daniel Duberstein, Susan Ferastraoaru, \| Galanopoulou, Aristea Galanopoulou, S Gursky, Jonathan Hanumanthu, Rajani Haut, Sheryl Hung, Christine Khodakivska, Olga Korey, Saul Legatt, Alan Molinero, Isaac Moshé, Solomon Patel, Puja Rosengard, Jillian Rubens, Elayna Sugrue, William Yozawitz, Elissa
Source	Medline; PMC
abstract	OBJECTIVE: Acute encephalopathy may occur in COVID‐19‐infected patients. We investigated whether medically indicated EEGs performed in acutely ill patients under investigation (PUIs) for COVID‐19 report epileptiform abnormalities and whether these are more prevalent in COVID‐19 positive than negative patients. METHODS: In this retrospective case series, adult COVID‐19 inpatient PUIs underwent EEGs for acute encephalopathy and/or seizure‐like events. PUIs had 8‐channel headband EEGs (Ceribell; 20 COVID‐19 positive, 6 COVID‐19 negative); 2 more COVID‐19 patients had routine EEGs. Overall, 26 Ceribell EEGs, 4 routine and 7 continuous EEG studies were reviewed. EEGs were interpreted by board‐certified clinical neurophysiologists (n = 16). EEG findings were correlated with demographic data, clinical presentation and history, and medication usage. Fisher's exact test was used. RESULTS: We included 28 COVID‐19 PUIs (30‐83 years old), of whom 22 tested positive (63.6% males) and 6 tested negative (33.3% male). The most common indications for EEG, among COVID‐19‐positive vs COVID‐19‐negative patients, respectively, were new onset encephalopathy (68.2% vs 33.3%) and seizure‐like events (14/22, 63.6%; 2/6, 33.3%), even among patients without prior history of seizures (11/17, 64.7%; 2/6, 33.3%). Sporadic epileptiform discharges (EDs) were present in 40.9% of COVID‐19‐positive and 16.7% of COVID‐19‐negative patients; frontal sharp waves were reported in 8/9 (88.9%) of COVID‐19‐positive patients with EDs and in 1/1 of COVID‐19‐negative patient with EDs. No electrographic seizures were captured, but 19/22 COVID‐19‐positive and 6/6 COVID‐19‐negative patients were given antiseizure medications and/or sedatives before the EEG. SIGNIFICANCE: This is the first preliminary report of EDs in the EEG of acutely ill COVID‐19‐positive patients with encephalopathy or suspected clinical seizures. EDs are relatively common in this cohort and typically appear as frontal sharp waves. Further studies are needed to confirm these findings and evaluate the potential direct or indirect effects of COVID‐19 on activating epileptic activity.
has issue date	2020-05-17(xsd:dateTime)
bibo:doi	10.1002/epi4.12399
bibo:pmid	32537529
has license	cc-by-nc-nd
sha1sum (hex)	edc9f47cc135f52b02d57a5aba598068455c9a06
schema:url	https://doi.org/10.1002/epi4.12399
resource representing a document's title	EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report
has PubMed Central identifier	PMC7289172
has PubMed identifier	32537529
schema:publication	Epilepsia Open
resource representing a document's body	covid:edc9f47cc135f52b02d57a5aba598068455c9a06#body_text
is schema:about of	named entity 'COVID-19' named entity 'patients' named entity 'abnormalities' named entity 'EEGs' named entity 'encephalopathy' named entity 'investigated' named entity 'headband' named entity 'EEGs' named entity 'EEGs' named entity 'epileptiform' named entity 'COVID-19' named entity 'case series' named entity 'electrodes' named entity 'EEG' named entity 'EEG' named entity 'EEG' named entity 'High pass filter' named entity 'epilepsy' named entity 'antiseizure medications' named entity 'COVID-19' named entity 'Altered mental status' named entity 'sedatives' named entity 'viruses' named entity 'brainstem' named entity 'Montefiore Medical Center' named entity 'COVID-19' named entity 'Montefiore Medical Center' named entity 'COVID-19' named entity 'Fisher's exact test' named entity 'encephalopathy' named entity 'EEGs' named entity 'COVID-19' named entity 'COVID-19' named entity 'SARS' named entity 'subarachnoid hemorrhage' named entity 'statistical significance' named entity 'seizure' named entity 'viral infections' named entity 'seizure' named entity 'CNS' named entity 'hepatic dysfunction' named entity 'EEG' named entity 'pneumonia' named entity 'seizures' named entity 'EEGs' named entity 'seizures' named entity 'encephalopathy' named entity 'infection' named entity 'EEG' named entity 'Neuroimaging' named entity 'nasopharyngeal' named entity 'encephalomalacia' named entity 'CSF' named entity 'COVID-19' named entity 'EEG' named entity 'neurological' named entity 'EEGs' named entity 'H3N2' named entity 'neurological'

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