About: TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
Creator	Chen, Yan Chen, Xue-Yan Man, Xiao-Yong Yan, Bing-Xi
Source	Medline; PMC; WHO
abstract	Increased inflammatory cytokines [such as tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6)] are observed in COVID-19 patients, especially in the severe group. The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1177/1753466620926800
bibo:pmid	32436460
has license	cc-by-nc
sha1sum (hex)	edc5c2f04ae6ba080f17b7a9462370c3067d22d3
schema:url	https://doi.org/10.1177/1753466620926800
resource representing a document's title	TNFα inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis
has PubMed Central identifier	PMC7243041
has PubMed identifier	32436460
schema:publication	Ther Adv Respir Dis
resource representing a document's body	covid:edc5c2f04ae6ba080f17b7a9462370c3067d22d3#body_text
is schema:about of	named entity 'SUPPRESSING' named entity 'INHIBITOR' named entity 'COVID-19' named entity 'RESPONSES' named entity 'TOXIC EPIDERMAL NECROLYSIS' named entity 'tumor necrosis factor alpha' named entity 'IL-6' named entity 'TNFα' named entity 'toxic epidermal necrolysis' named entity 'Toxic epidermal necrolysis' named entity 'trachea' named entity 'TNF-α' named entity 'pathogenesis' named entity 'comorbidities' named entity 'Toxic epidermal necrolysis' named entity 'inducer' named entity 'COVID-19' named entity 'Th1' named entity 'COVID-19' named entity 'bronchi' named entity 'IL-2' named entity 'lymphocyte count' named entity 'TNFα' named entity 'toxic epidermal necrolysis' named entity 'immune cells' named entity 'cDC' named entity 'life-threatening' named entity 'Interstitial thickening' named entity 'acute lung injury' named entity 'COVID' named entity 'intensive care unit' named entity 'type II' named entity 'ICU' named entity 'COVID' named entity 'Lung tissue' named entity 'histological examination' named entity 'normal range' named entity 'myalgia' named entity 'interferon' named entity 'oxygen therapy' named entity 'hyaline' named entity 'pulmonary edema' named entity 'systemic disease' named entity 'China' named entity 'ACE2' named entity 'innate immune' named entity 'dry cough' named entity 'monocytes' named entity 'Th17' named entity 'ACE2' named entity 'inflammatory cells' named entity 'TNFα' named entity 'COVID-19' named entity 'interleukin 8' named entity 'Toxic epidermal necrolysis' named entity 'virus' named entity 'cytokine storm' named entity 'antibiotic' named entity 'necrosis' named entity 'staining' named entity 'COVID-19' named entity 'lymphocyte' named entity 'intravascular' named entity 'white blood cell count' named entity 'antiviral drugs' named entity 'cytokine' named entity 'cytokine' named entity 'fatigue' named entity 'Toxic epidermal necrolysis' named entity 'China' named entity 'pulmonary malignancy' named entity 'ICU' named entity 'aspartate transaminase' named entity 'sore throat' named entity 'inflammatory markers' named entity 'organ' named entity 'immunopathogenesis' named entity 'Etanercept'

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