About: Development and validation of serological assays for viral hemorrhagic fevers and determination of the prevalence of Rift Valley fever in Borno State, Nigeria

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About: Development and validation of serological assays for viral hemorrhagic fevers and determination of the prevalence of Rift Valley fever in Borno State, Nigeria Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development and validation of serological assays for viral hemorrhagic fevers and determination of the prevalence of Rift Valley fever in Borno State, Nigeria
Creator	Fukushi, Shuetsu Morikawa, Shigeru Saijo, Masayuki Taniguchi, Satoshi Fukuma, Aiko Shimojima, Masayuki Tani, Hideki Yoshikawa, Tomoki Kasolo, Francis Iha, Koichiro Nadeba Bukbuk, David Saheed Baba, Saka
Source	Medline; PMC
abstract	BACKGROUND: Rift Valley fever (RVF) is endemic to the tropical regions of eastern and southern Africa. The seroprevalence of RVF was investigated among the human population in Borno State, Nigeria to determine the occurrence of the disease in the study area in comparison with that of Lassa fever and Crimean-Congo Hemorrhagic fever. METHODS: Recombinant nucleoprotein (rNP)-based IgG-ELISAs for the detection of serum antibodies against RVF virus (RVFV), Lassa fever virus (LASV), and Crimean-Congo hemorrhagic fever virus (CCHFV) were used to test human sera in Borno State, Nigeria. The presence of neutralizing antibody against the RVFV-glycoprotein-bearing vesicular stomatitis virus pseudotype (RVFVpv) was also determined in the human sera. RESULTS: Of the 297 serum samples tested, 42 (14.1%) were positive for the presence of RVFV-IgG and 22 (7.4%) and 7 (2.4%) of the serum samples were positive for antibodies against LASV and CCHFV, respectively. There was a positive correlation between the titers of neutralizing antibodies obtained using RVFVpv and those obtained using the conventional neutralization assay with the attenuated RVFV-MP12 strain. CONCLUSIONS: The seroprevalence of RVF was significantly higher than that of LASV and CCHF in Borno State, Nigeria. The RVFVpv-based neutralization assay developed in this study has the potential to replace the traditional assays based on live viruses for the diagnosis and seroepidemiological studies of RVF.
has issue date	2014-10-24(xsd:dateTime)
bibo:doi	10.1093/trstmh/tru163
bibo:pmid	25344695
has license	no-cc
sha1sum (hex)	eda4b00244cb209f8e7d16463c8f6270f26d398c
schema:url	https://doi.org/10.1093/trstmh/tru163
resource representing a document's title	Development and validation of serological assays for viral hemorrhagic fevers and determination of the prevalence of Rift Valley fever in Borno State, Nigeria
has PubMed Central identifier	PMC7107251
has PubMed identifier	25344695
schema:publication	Trans R Soc Trop Med Hyg
resource representing a document's body	covid:eda4b00244cb209f8e7d16463c8f6270f26d398c#body_text
is schema:about of	named entity 'Borno' named entity 'PREVALENCE' named entity 'DEVELOPMENT' named entity 'DISEASE' named entity 'INVESTIGATED' named entity 'RIFT VALLEY FEVER' named entity 'RVF' named entity 'BACKGROUND' named entity 'RIFT VALLEY FEVER' named entity 'SEROPREVALENCE' named entity 'BORNO STATE' named entity 'EASTERN' named entity 'LASSA FEVER' named entity 'ENDEMIC' named entity 'DETERMINATION' named entity 'OCCURRENCE' named entity 'CRIMEAN-CONGO HEMORRHAGIC FEVER' named entity 'COMPARISON' named entity 'NIGERIA' named entity 'VALIDATION' named entity 'BORNO STATE' named entity 'SEROLOGICAL' named entity 'VIRAL HEMORRHAGIC FEVERS' named entity 'HUMAN POPULATION' named entity 'SOUTHERN AFRICA' named entity 'TROPICAL REGIONS' named entity 'NIGERIA' named entity 'DETERMINE' covid:arg/eda4b00244cb209f8e7d16463c8f6270f26d398c named entity 'endemic' named entity 'Crimean-Congo Hemorrhagic fever' named entity 'serological' named entity 'southern Africa' named entity 'serological' named entity 'Borno State' named entity 'serum' named entity 'St. Louis' named entity 'luciferase' named entity 'pseudotype' named entity 'pseudotype' named entity 'Nigeria' named entity 'glycoproteins' named entity 'VSV' named entity 'Cameroun' named entity 'rNP' named entity 'Borno State' named entity 'endemic' named entity 'luciferase' named entity 'RVF' named entity 'infectious diseases' named entity 'Lassa fever' named entity 'sensitivity and specificity' named entity 'RVF' named entity 'antibodies' named entity 'RVFV' named entity 'IgG' named entity 'pseudotyped' named entity 'Nigeria' named entity 'infection' named entity 'serum' named entity 'viral hemorrhagic fevers' named entity 'RVFV' named entity 'VSVG' named entity 'VSV' named entity 'RVFV' named entity 'Nigeria' named entity 'RVFV' named entity 'Lassa fever' named entity 'titer' named entity 'luciferase'

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