About: Adenovirus flow in host cell networks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Adenovirus flow in host cell networks
Creator	Butcher, Sarah Flatt, Justin
source	PMC
abstract	Viruses are obligatory parasites that take advantage of intracellular niches to replicate. During infection, their genomes are carried in capsids across the membranes of host cells to sites of virion production by exploiting cellular behaviour and resources to guide and achieve all aspects of delivery and the downstream virus manufacturing process. Successful entry hinges on execution of a precisely tuned viral uncoating program where incoming capsids disassemble in consecutive steps to ensure that genomes are released at the right time, and in the right place for replication to occur. Each step of disassembly is cell-assisted, involving individual pathways that transmit signals to regulate discrete functions, but at the same time, these signalling pathways are organized into larger networks, which communicate back and forth in complex ways in response to the presence of virus. In this review, we consider the elegant strategy by which adenoviruses (AdVs) target and navigate cellular networks to initiate the production of progeny virions. There are many remarkable aspects about the AdV entry program; for example, the virus gains targeted control of a large well-defined local network neighbourhood by coupling several interacting processes (including endocytosis, autophagy and microtubule trafficking) around a collective reference state centred on the interactional topology and multifunctional nature of protein VI. Understanding the network targeting activity of protein VI, as well as other built-in mechanisms that allow AdV particles to be efficient at navigating the subsystems of the cell, can be used to improve viral vectors, but also has potential to be incorporated for use in entirely novel delivery systems.
has issue date	2019-02-27(xsd:dateTime)
bibo:doi	10.1098/rsob.190012
bibo:pmid	30958097
has license	cc-by
sha1sum (hex)	ed4d4c0c8e8a99060cb7347585bbbeff3c823193
schema:url	https://doi.org/10.1098/rsob.190012
resource representing a document's title	Adenovirus flow in host cell networks
has PubMed Central identifier	PMC6395880
has PubMed identifier	30958097
schema:publication	Open Biol
resource representing a document's body	covid:ed4d4c0c8e8a99060cb7347585bbbeff3c823193#body_text
is schema:about of	named entity 'microtubule' named entity 'discrete' named entity 'target' named entity 'adenoviruses' named entity 'cells' named entity 'centred' named entity 'LOCAL' named entity 'ENSURE' named entity 'AUTOPHAGY' named entity 'PROGENY' named entity 'INDIVIDUAL' named entity 'DISASSEMBLE' named entity 'INFECTION' named entity 'DISCRETE' named entity 'NATURE' named entity 'improve' named entity 'presence' named entity 'aspects' named entity 'protein' named entity 'niches' named entity 'gains' named entity 'AdV' named entity 'viral' named entity 'mechanisms' named entity 'hinges' named entity 'tuned' named entity 'carried' named entity 'behaviour' named entity 'host' named entity 'parasites' named entity 'virion' named entity 'discrete functions' named entity 'virus' named entity 'virus' named entity 'host cells' named entity 'viral vectors' named entity 'virus' named entity 'intracellular' named entity 'host cell' named entity 'nuclear envelope' named entity 'intermolecular forces' named entity 'relaxes the constraints' named entity 'vectors' named entity 'genome' named entity 'virions' named entity 'protein' named entity 'lattice' named entity 'immune responses' named entity 'microtubules' named entity 'biological engineering' named entity 'integrins' named entity 'AdV' named entity 'hexons' named entity 'clathrin' named entity 'viral protease' named entity 'icosahedral' named entity 'hexon' named entity 'uncoating' named entity 'defensins' named entity 'uncoating' named entity 'Capsids' named entity 'hexons' named entity 'uncoating' named entity 'virus' named entity 'infection' named entity 'lipid bilayer' named entity 'AdV' named entity 'hexons' named entity 'protein' named entity 'virions' named entity 'immunocompromised' named entity 'outer surface' named entity 'endocytic' named entity 'virus particle' named entity 'virus particle' named entity 'cytoskeletal network' named entity 'viral genome' named entity 'protein' named entity 'virus' named entity 'Mexican beaded lizard'

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