About: A Mechanism of Virus-Induced Demyelination

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Mechanism of Virus-Induced Demyelination
Creator	Das Sarma, Jayasri
Source	Medline; PMC
abstract	Myelin forms an insulating sheath surrounding axons in the central and peripheral nervous systems and is essential for rapid propagation of neuronal action potentials. Demyelination is an acquired disorder in which normally formed myelin degenerates, exposing axons to the extracellular environment. The result is dysfunction of normal neuron-to-neuron communication and in many cases, varying degrees of axonal degeneration. Numerous central nervous system demyelinating disorders exist, including multiple sclerosis. Although demyelination is the major manifestation of most of the demyelinating diseases, recent studies have clearly documented concomitant axonal loss to varying degrees resulting in long-term disability. Axonal injury may occur secondary to myelin damage (outside-in model) or myelin damage may occur secondary to axonal injury (inside-out model). Viral induced demyelination models, has provided unique imminent into the cellular mechanisms of myelin destruction. They illustrate mechanisms of viral persistence, including latent infections, virus reactivation and viral-induced tissue damage. These studies have also provided excellent paradigms to study the interactions between the immune system and the central nervous system (CNS). In this review we will discuss potential cellular and molecular mechanism of central nervous system axonal loss and demyelination in a viral induced mouse model of multiple sclerosis.
has issue date	2010-06-21(xsd:dateTime)
bibo:doi	10.1155/2010/109239
bibo:pmid	20652053
has license	no-cc
sha1sum (hex)	ed41111b7ec211ae5ad254835306b8a92567411d
schema:url	https://doi.org/10.1155/2010/109239
resource representing a document's title	A Mechanism of Virus-Induced Demyelination
has PubMed Central identifier	PMC2905936
has PubMed identifier	20652053
schema:publication	Interdiscip Perspect Infect Dis
resource representing a document's body	covid:ed41111b7ec211ae5ad254835306b8a92567411d#body_text
is schema:about of	named entity 'loss' named entity 'immune system' named entity 'inside-out' named entity 'viral' named entity 'manifestation' named entity 'excellent' named entity 'damage' named entity 'communication' named entity 'disorders' named entity 'acquired disorder' named entity 'The' named entity 'degeneration' named entity 'insulating' named entity 'demyelinating diseases' named entity 'paradigms' named entity 'normal' named entity 'virus' named entity 'essential' named entity 'Myelin' named entity 'secondary' named entity 'demyelinating diseases' named entity 'multiple sclerosis' named entity 'axons' named entity 'neuron' named entity 'virus' named entity 'tissue damage' named entity 'myelin' named entity 'Demyelination' named entity 'long-term' named entity 'multiple sclerosis' named entity 'disability' named entity 'action potentials' named entity 'Demyelination' named entity 'cellular' named entity 'CD8+ T cells' named entity 'neurons' named entity 'toluidine blue' named entity 'infection' named entity 'genome' named entity 'CD11b' named entity 'MHV' named entity 'demyelinating lesions' named entity 'gray matter' named entity 'infection' named entity 'myelin' named entity 'MHV' named entity 'white matter lesions' named entity 'hypersensitivity response' named entity 'TMEV' named entity 'oligodendrocytes' named entity 'macrophage' named entity 'fluorescence' named entity 'antigen' named entity 'EGFP' named entity 'virions' named entity 'ADEM' named entity 'inoculation' named entity 'leukoencephalopathy' named entity 'microglia' named entity 'lytic infection' named entity 'phenotypes' named entity 'EGFP' named entity 'replicase' named entity 'viruses' named entity 'white matter lesions' named entity 'MHV' named entity 'spinal cords' named entity 'immune-mediated' named entity 'demyelination' named entity 'myelin' named entity 'astrocytic' named entity 'expression of the gene' named entity 'mice' named entity 'protein' named entity 'RNA' named entity 'cross-reacts' named entity 'wild-type virus' named entity 'vertebrate' named entity 'MHV' named entity 'carcinoembryonic antigen' named entity 'protein'

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