About: Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies

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About: Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
Creator	Sugiyama, K Hatakeyama, K Kasai, H Morita, E
source	Medline; PMC
abstract	We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3Aff28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5Aff3, 6Aff6, 13Aff4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.
has issue date	2014-04-08(xsd:dateTime)
bibo:doi	10.1007/s007050050431
bibo:pmid	9856082
has license	no-cc
sha1sum (hex)	ed3104cc4a425f7fa79cdf959965566dc1d56dae
schema:url	https://doi.org/10.1007/s007050050431
resource representing a document's title	Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
has PubMed Central identifier	PMC7086726
has PubMed identifier	9856082
schema:publication	Arch Virol
resource representing a document's body	covid:ed3104cc4a425f7fa79cdf959965566dc1d56dae#body_text
is schema:about of	named entity 'activity' named entity 'activity' named entity 'cell fusion' named entity 'activities' named entity 'glycoprotein' named entity 'murine' named entity 'PROTEIN ' named entity 'CORONA' named entity 'CHARACTERIZATION' named entity 'GROUP A' named entity 'SIMILAR' named entity 'MONOCLONAL ANTIBODIES' named entity 'RESULTS' named entity 'PLAY' named entity 'VIRUS' named entity 'WEAK' named entity 'REFERRED TO' named entity 'THESE' named entity 'ACTIVITY' named entity 'GROUPS' named entity 'GROUP B' named entity 'INHIBITED' named entity 'HAND' named entity 'MHV-S' named entity 'INFECTED' named entity 'MICE' named entity 'SEVEN' named entity 'ESTERASE' named entity 'HAEMAGGLUTININ' named entity 'FUNCTIONAL SITES' named entity 'ROLES' named entity 'MURINE' named entity 'VIRUS' named entity 'ESTERASE' named entity 'SUGGEST' named entity 'RAISED' named entity 'DESIGNATED' named entity 'MONOCLONAL ANTIBODIES' named entity 'CHARACTERISTICS' named entity 'CLASSIFIED' named entity 'MURINE CORONAVIRUS' named entity 'CELLS' named entity 'IMPORTANT' named entity 'BUT' named entity 'THE CELL' named entity 'ANALYZED' named entity 'INFANT' named entity 'CELL FUSION' named entity 'IDENTICAL' named entity 'EPITOPES' named entity 'GLYCOPROTEIN' named entity 'PURIFIED' named entity 'ACTIVITIES' named entity 'INHIBITION' named entity 'RATIO' covid:arg/ed3104cc4a425f7fa79cdf959965566dc1d56dae named entity 'ratio' named entity 'diarrhea' named entity 'esterase' named entity 'positive polarity' named entity 'glycoprotein' named entity 'titer' named entity 'haemagglutination' named entity 'mAbs' named entity 'Neutralization tests' named entity 'inhibited' named entity 'activities' named entity 'murine coronavirus' named entity 'monoclonal antibodies' named entity 'epitopes' named entity 'glycoprotein' named entity 'mAbs' named entity 'antigenic' named entity 'esterase' named entity 'murine' named entity 'p-nitrophenol' named entity 'mAb' named entity 'titer'

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