About: Quasispecies as a matter of fact: Viruses and beyond

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Quasispecies as a matter of fact: Viruses and beyond
Creator	Domingo, Esteban Perales, Celia Ojosnegros, Samuel Mas, Antonio
source	Elsevier; Medline; PMC
abstract	Abstract We review the origins of the quasispecies concept and its relevance for RNA virus evolution, viral pathogenesis and antiviral treatment strategies. We emphasize a critical point of quasispecies that refers to genome collectivities as the unit of selection, and establish parallels between RNA viruses and some cellular systems such as bacteria and tumor cells. We refer also to tantalizing new observations that suggest quasispecies behavior in prions, perhaps as a result of the same quantum-mechanical indeterminations that underlie protein conformation and error-prone replication in genetic systems. If substantiated, these observations with prions could lead to new research on the structure–function relationship of non-nucleic acid biological molecules.
has issue date	2011-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2011.09.018
bibo:pmid	21945638
has license	els-covid
sha1sum (hex)	ed0a8e9cfc0bd4aeb2fdd0cfc5aff8e3918deeff
schema:url	https://doi.org/10.1016/j.virusres.2011.09.018
resource representing a document's title	Quasispecies as a matter of fact: Viruses and beyond
has PubMed Central identifier	PMC7172439
has PubMed identifier	21945638
schema:publication	Virus Research
resource representing a document's body	covid:ed0a8e9cfc0bd4aeb2fdd0cfc5aff8e3918deeff#body_text
is schema:about of	named entity 'lead' named entity 'STRUCTURE-FUNCTION RELATIONSHIP' named entity 'UNIT' named entity 'TUMOR CELLS' named entity 'MECHANICAL' named entity 'PRIONS' named entity 'parallels' named entity 'refers' named entity 'quasispecies' named entity 'quasispecies' named entity 'unit' named entity 'prions' named entity 'tumor cells' named entity 'quasispecies' named entity 'Viruses' named entity 'viruses' named entity 'cancer cells' named entity 'probability' named entity 'virulent' named entity 'coinfect' named entity 'virulent' named entity 'diffusion' named entity 'RNA phage' named entity 'nucleic acids' named entity 'quasispecies' named entity 'dental plaque' named entity 'genomes' named entity 'mutagen' named entity 'biological function' named entity 'life insurance' named entity 'biofilm' named entity 'evolution' named entity 'quasispecies' named entity 'virulent' named entity 'Sacristan' named entity 'probability' named entity 'Froissart' named entity 'foot-and-mouth disease virus' named entity 'infectivity' named entity 'prion' named entity 'mutagenesis' named entity 'RNA viruses' named entity 'pathogenic agents' named entity 'chromosomal rearrangements' named entity 'quasispecies' named entity 'quasispecies' named entity 'non-genetic' named entity 'phenotypes' named entity 'Schuster' named entity 'cell culture' named entity 'virus' named entity 'RNA world' named entity 'DNA denaturation' named entity 'population structure' named entity 'Eigen' named entity 'quasispecies' named entity 'RNA viruses' named entity 'molecular mechanisms' named entity 'mutation rate' named entity 'virus' named entity 'extracellular' named entity 'mutation' named entity 'synergistically' named entity 'diffusion' named entity 'virus' named entity 'mutation' named entity 'RNA virus' named entity 'virus' named entity 'genomes' named entity 'Eigen' named entity 'MOI' named entity 'mutagenic agents' named entity 'complex systems' named entity 'genomes' named entity 'unit of selection' named entity 'mutator phenotype' named entity 'Darwinian' named entity 'biological systems'

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