About: Spleen and Liver

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spleen and Liver
Creator	Torimura, Takuji
topic	covid:ecaff09ee4b30749a779a72e13569a61ddd9d52d#this
Source	PMC
abstract	In liver cirrhosis, the spleen is a source of nitric oxide which affects a hyperdynamic state typical of portal hypertension. It is generally accepted that pancytopenia results predominantly from the increased phagocytosis and destruction of hemocytes in splenic macrophages. In addition, liver fibrosis is amplified by migrated Th2 lymphocytes and transforming growth factor beta from the spleen. There is a possibility that increase of the spleen stiffness is the primary factor of idiopathic portal hypertension. Spleen stiffness is caused by bleeding, fibrosis, and calcareous deposits after increase in red pulp pressure due to venous congestion. In nonalcoholic steatohepatitis, macrophage activity in the spleen is upregulated. In addition, high levels of inflammatory cytokines are produced and T cell shows increased proliferation in the spleen. In autoimmune hepatitis model, CD4(+) T cells are differentiated into follicular helper T cells (T(FH)) in the spleen. T(FH) cells promoted hypergammaglobulinemia and antinuclear antibodies production. T(FH) cells migrate from the spleen to the liver, triggering induction of autoimmune hepatitis in this model. IgM-positive B cells localize in the CD21-positive lymph follicle in the spleen of primary biliary cholangitis. These findings prove that the spleen influences on the pathogenesis and severity of several kinds of liver disease.
has issue date	2016-03-03(xsd:dateTime)
bibo:doi	10.1007/978-4-431-55790-6_3
has license	no-cc
sha1sum (hex)	ecaff09ee4b30749a779a72e13569a61ddd9d52d
schema:url	https://doi.org/10.1007/978-4-431-55790-6_3
resource representing a document's title	Spleen and Liver
has PubMed Central identifier	PMC7122130
schema:publication	The Liver in Systemic Diseases
resource representing a document's body	covid:ecaff09ee4b30749a779a72e13569a61ddd9d52d#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ecaff09ee4b30749a779a72e13569a61ddd9d52d
is schema:about of	named entity 'liver cirrhosis' named entity 'INCREASED PHAGOCYTOSIS' named entity 'RESULTS' named entity 'NITRIC OXIDE' named entity 'SPLEEN' named entity 'spleen' named entity 'hemocytes' named entity 'phagocytosis' named entity 'nitric oxide' named entity 'macrophages' named entity 'hemocytes' named entity 'portal hypertension' named entity 'stiffness' named entity 'downregulation' named entity 'isoforms' named entity 'CXCR5' named entity 'germinal center' named entity 'inflammatory cells' named entity 'neonatal' named entity 'hyperplasia' named entity 'ionomycin' named entity 'antigenic' named entity 'Toll-like receptor 9' named entity 'antigenic' named entity 'prostacyclin' named entity 'liver' named entity 'TGF beta' named entity 'spleen' named entity 'adrenomedullin' named entity 'lymphocytes' named entity 'Experimental studies' named entity 'immune dysregulation' named entity 'hepatocyte growth factor' named entity 'receptor' named entity 'idiopathic' named entity 'autoimmune hepatitis' named entity 'phagocytosis' named entity 'steatosis' named entity 'stellate cells' named entity 'blood flow' named entity 'platelets' named entity 'autocrine' named entity 'platelets' named entity 'Th2' named entity 'blood flow' named entity 'antigens' named entity 'fibrosis' named entity 'HGF' named entity 'endothelium-derived hyperpolarizing factor' named entity 'relapse' named entity 'Th1' named entity 'stiffness' named entity 'Primary biliary cholangitis' named entity 'venous flow' named entity 'memory B cells' named entity 'CpG' named entity 'endocannabinoids' named entity 'platelet' named entity 'antigen' named entity 'cirrhotic' named entity 'insulin resistance' named entity 'liver fibrosis' named entity 'antibody' named entity 'blood cells' named entity 'lymphocytes' named entity 'erythrocytes' named entity 'Splenectomy' named entity 'liver' named entity 'pathogenesis' named entity 'peripheral blood' named entity 'hematological' named entity 'sinusoidal endothelial cells' named entity 'red pulp' named entity 'autoimmune hepatitis' named entity 'splanchnic circulation' named entity 'splanchnic circulation' named entity 'PD-1' named entity 'spleen' named entity 'splanchnic circulation' named entity 'CD8 +' named entity 'liver'

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