About: Intrahost Diversity of Feline Coronavirus: A Consensus between the Circulating Virulent/Avirulent Strains and the Internal Mutation Hypotheses?

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About: Intrahost Diversity of Feline Coronavirus: A Consensus between the Circulating Virulent/Avirulent Strains and the Internal Mutation Hypotheses? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Intrahost Diversity of Feline Coronavirus: A Consensus between the Circulating Virulent/Avirulent Strains and the Internal Mutation Hypotheses?
Creator	Maiorka, Paulo Asano, Karen Brandão, Paulo Hora, Aline Richtzenhain, Leonardo Guerra, Juliana Mesquita, Ramon
Source	Medline; PMC
abstract	To evaluate the most controversial issue concerning current feline coronavirus (FCoV) virology, the coexisting hypotheses of the intrahost and interhost origins of feline infectious peritonitis virus (FIPV) in regard to the pathogenesis of feline infectious peritonitis (FIP), this study aimed to assess the molecular diversity of the membrane gene FCoVs in 190 samples from 10 cats with signs of FIP and in 5 faecal samples from cats without signs of FIP. All samples from the non-FIP cats and 25.26% of the samples from the FIP cats were positive for the FCoV membrane (M) gene. Mutations in this gene consisted of SNP changes randomly scattered among the sequences; few mutations resulted in amino acid changes. No geographic pattern was observed. Of the cats without FIP that harboured FECoV, the amino acid sequence identities for the M gene were 100% among cats (Cats 1–3) from the same cattery, and the overall sequence identity for the M gene was ≥91%. In one cat, two different lineages of FCoV, one enteric and one systemic, were found that segregated apart in the M gene tree. In conclusion, the in vivo mutation transition hypothesis and the circulating high virulent-low virulent FCoV hypothesis have been found to be plausible according to the results obtained from sequencing the M gene.
has issue date	2013-03-27(xsd:dateTime)
bibo:doi	10.1155/2013/572325
bibo:pmid	23589704
has license	cc-by
sha1sum (hex)	ec9ad2ac0be589d617f25f1cfc349f644d1bebf1
schema:url	https://doi.org/10.1155/2013/572325
resource representing a document's title	Intrahost Diversity of Feline Coronavirus: A Consensus between the Circulating Virulent/Avirulent Strains and the Internal Mutation Hypotheses?
has PubMed Central identifier	PMC3622387
has PubMed identifier	23589704
schema:publication	ScientificWorldJournal
resource representing a document's body	covid:ec9ad2ac0be589d617f25f1cfc349f644d1bebf1#body_text
is schema:about of	named entity 'CIRCULATING' named entity 'VIRULENT' named entity 'assess' named entity 'sequence identity' named entity 'Mutations' named entity 'EVALUATE' named entity 'STRAINS' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'HIGH' named entity 'IDENTITIES' named entity 'CONCLUSION' named entity 'OVERALL' named entity 'HYPOTHESIS' named entity 'FIP' named entity 'ENTERIC' named entity 'FOUND' named entity 'TRANSITION' named entity 'POSITIVE FOR' named entity 'PATHOGENESIS' named entity 'MUTATION' named entity 'CATS' named entity 'AMINO ACID' named entity 'VIRULENT' named entity 'FAECAL' named entity 'DIVERSITY' named entity 'MUTATION' named entity 'AMINO ACID SEQUENCE' named entity 'INTERNAL' named entity 'FELINE CORONAVIRUS' named entity 'REGARD' named entity 'ASSESS' named entity '100%' named entity 'SIGNS' named entity 'CHANGES' named entity 'DIFFERENT' named entity 'IN VIVO' named entity 'VIROLOGY' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'GENE TREE' named entity 'MUTATIONS' named entity 'DIVERSITY' named entity 'SEQUENCING' named entity 'MOLECULAR' named entity '190' named entity 'OBTAINED' named entity 'SCATTERED' named entity 'CURRENT' named entity 'STUDY' named entity 'GENE' named entity 'ORIGINS' named entity 'NON-' named entity 'MEMBRANE' named entity 'ACCORDING' named entity 'GEOGRAPHIC' named entity 'SAMPLES' named entity 'SEQUENCE IDENTITY' named entity 'SYSTEMIC' named entity 'RESULTS' named entity 'PATTERN' named entity 'CIRCULATING' named entity 'FELINE CORONAVIRUS' named entity 'ISSUE' named entity 'APART' named entity 'CAT' named entity 'SEQUENCES' named entity 'CONSENSUS' named entity 'M GENE' named entity 'LOW' named entity 'HAVE' named entity 'OBSERVED' named entity 'SNP' covid:arg/ec9ad2ac0be589d617f25f1cfc349f644d1bebf1 named entity 'gene' named entity 'samples' named entity 'randomly'

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