About: HHV-6B Induces IFN-Lambda1 Responses in Cord Plasmacytoid Dendritic Cells through TLR9

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About: HHV-6B Induces IFN-Lambda1 Responses in Cord Plasmacytoid Dendritic Cells through TLR9 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HHV-6B Induces IFN-Lambda1 Responses in Cord Plasmacytoid Dendritic Cells through TLR9
Creator	Eriksson, Kristina Sandberg, Johan Institutet, Karolinska Nordströ, Inger Sweden,
Source	Medline; PMC
abstract	Human herpesvirus type 6B (HHV-6B) is a strong inducer of IFN-alpha and has the capacity to promote Th1 responses and block Th2 responses in vitro. In this study we addressed whether inactivated HHV-6B can also induce IFN lambda responses and to what extent interferons alpha and lambda affect Th1/Th2 polarization. We show that inactivated HHV-6B induced IFN-lambda1 (IL-29) but not IFN-lambda2 (IL-28A) responses in plasmacytoid DC and that this induction was mediated through TLR9. We have previously shown that HHV-6B promotes Th1 responses and blocks Th2 responses in both humans and mice. We now show that neutralization of IFN-alpha but not IFN-lambda1 blocked the HHV-6B-induced enhancement of Th1 responses in MLR, but did not affect the HHV-6-induced dampening of Th2 responses. Similarly, blockage of TLR9 counteracted HHV-6Bs effects on the Th1/Th2 balance. In addition, IFN-alpha but not IFN-lambda1 promoted IFN-gamma production and blocked IL-5 and IL-13 production in purified CD4+ T-cells. The lack of effect of IFN-lambda1 correlated with the absence of the IFN-lambda receptor IL-28Ralfa chain on the cell surface of both resting and activated CD4+ T-cells. We conclude that inactivated HHV-6B is a strong inducer of IFN-lambda1 in plasmacytoid DC and that this induction is TLR9-dependent. However, human CD4+ T-cells do not express the IFN-lambda receptor and are refractory to IFN-lambda1 treatment. The HHV-6B-induced alterations in the Th1/Th2 balance are instead mediated mainly through TLR9 and IFN-alpha.
has issue date	2012-06-06(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0038683
bibo:pmid	22701693
has license	cc-by
sha1sum (hex)	ec7e7937ff0f3f8561b73eb8a4d34de49e35e3ff
schema:url	https://doi.org/10.1371/journal.pone.0038683
resource representing a document's title	HHV-6B Induces IFN-Lambda1 Responses in Cord Plasmacytoid Dendritic Cells through TLR9
has PubMed Central identifier	PMC3368904
has PubMed identifier	22701693
schema:publication	PLoS One
resource representing a document's body	covid:ec7e7937ff0f3f8561b73eb8a4d34de49e35e3ff#body_text
is schema:about of	named entity 'Th2' named entity 'plasmacytoid' named entity 'responses' named entity 'effects' named entity 'responses' named entity 'purified' named entity 'IFN-gamma' named entity 'BLOCKS' named entity 'PURIFIED' named entity 'IFN' named entity 'HHV' named entity 'ALPHA' named entity 'AFFECT' named entity 'RECEPTOR' named entity 'CELL SURFACE' named entity 'HHV-6' named entity 'REFRACTORY' named entity 'TREATMENT' named entity 'CHAIN' covid:arg/ec7e7937ff0f3f8561b73eb8a4d34de49e35e3ff named entity 'CONCLUDE' named entity 'EXPRESS' named entity 'MICE' named entity 'HUMAN HERPESVIRUS' named entity 'THE CELL' named entity 'ADDITION' named entity 'INDUCED' named entity 'ABSENCE OF' named entity 'HUMAN' named entity 'T-CELLS' named entity 'EFFECT' named entity 'CORD' named entity 'PLASMACYTOID DC' named entity 'TH1' named entity 'IFN-GAMMA PRODUCTION' named entity 'IL-5' named entity 'BUT' named entity 'ALTERATIONS' named entity 'EFFECTS' named entity 'DENDRITIC CELLS' named entity 'PLASMACYTOID' named entity 'IFN' named entity 'RESPONSES' named entity 'BALANCE' named entity 'DID' named entity 'ENHANCEMENT' named entity 'DO NOT' named entity 'INDUCTION' named entity 'CAPACITY' named entity 'HUMANS' named entity 'INTERFERONS' named entity 'PREVIOUSLY' named entity 'CD4' named entity 'BLOCKED' named entity 'HAVE' named entity 'IN VITRO' named entity 'STUDY' named entity '28A' named entity 'BLOCK' named entity 'INACTIVATED' named entity 'RESTING' named entity 'WHAT' named entity 'ACTIVATED' named entity 'TLR9' named entity 'BLOCKAGE' named entity 'MEDIATED' named entity 'MLR' named entity 'CORRELATED' named entity 'TYPE' named entity 'LAMBDA' named entity 'EXTENT' named entity 'IS A' named entity 'STRONG' named entity 'INDUCER' named entity 'TLR9' named entity 'POLARIZATION' named entity 'PROMOTE'

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