About: WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection

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About: WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection
Creator	Cui, Zhu Rogers, Erin Vyakarnam, Annapurna Fish, Eleanor Wang, Ben Ressler, Steven Rowley, David
Source	Elsevier; Medline; PMC
abstract	Abstract The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20−/− compared to ps20+/+ mice. Accompanying MHV-1 infection we observe an increase in the number of neutrophils infiltrating the BAL and an increase in the percentage of neutrophils in the lung draining lymph nodes of ps20−/− compared with ps20+/+ mice. Gene expression levels for the neutrophil chemoattractants CXCL1 and CXCL2 are elevated in the lungs of ps20−/− mice post-MHV-1 infection. Characterization of the immune cell profile in naïve ps20−/− mice revealed an increase in circulating neutrophils compared to ps20+/+ mice. No notable differences in other immune cell profiles were observed between the ps20+/+ and ps20−/− mice. Accordingly, we examined MHV-1 infection of neutrophils and provide evidence that neutrophils isolated from ps20−/− mice are more susceptible to MHV-1 infection than neutrophils isolated from ps20+/+ mice. These data suggest roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection.
has issue date	2012-11-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2012.08.012
bibo:pmid	22960155
has license	els-covid
sha1sum (hex)	ec47b31ce37d044e098dfb9cc29268b3cb437899
schema:url	https://doi.org/10.1016/j.antiviral.2012.08.012
resource representing a document's title	WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection
has PubMed Central identifier	PMC7114264
has PubMed identifier	22960155
schema:publication	Antiviral Research
resource representing a document's body	covid:ec47b31ce37d044e098dfb9cc29268b3cb437899#body_text
is schema:about of	named entity 'regulating' named entity 'MHV' named entity 'isolated' named entity 'neutrophil' named entity 'MURINE HEPATITIS VIRUS' named entity 'OBSERVE' named entity 'SUSCEPTIBILITY' named entity 'INCREASED' named entity 'CONTRASTING' named entity 'INCREASE' named entity 'EXPRESSION' named entity 'THE LUNGS' named entity 'DATA' named entity 'POST' named entity 'CHEMOTACTIC FACTORS' named entity 'LUNG' named entity 'ROLE' named entity 'SUGGEST' named entity 'FACTOR' named entity 'HIV INFECTION' named entity 'INFILTRATING' covid:arg/ec47b31ce37d044e098dfb9cc29268b3cb437899 named entity 'CELL PROFILE' named entity 'RESULTS' named entity 'CXCL1' named entity 'MHV-1' named entity 'FAMILY MEMBER' named entity 'DESCRIBE' named entity 'COMPARED' named entity 'WFDC1' named entity 'NEUTROPHIL' named entity 'RESPONSE TO' named entity 'HOST FACTOR' named entity 'REGULATING' named entity 'RESPIRATORY INFECTION' named entity 'WFDC1' named entity 'USING' named entity 'GENE EXPRESSION LEVELS' named entity 'IMMUNE CELL' named entity 'KNOCKOUT MICE' named entity 'INFECTION' named entity 'NEUTROPHIL' named entity 'CXCL2' named entity 'PS20' named entity 'INFECTION' named entity 'CIRCULATING' named entity 'VIRAL' named entity '80%' named entity 'PERCENTAGE' named entity 'BAL' named entity 'ROLES' named entity 'SUSCEPTIBLE' named entity 'LYMPH NODES' named entity 'INTRANASAL' named entity 'EVIDENCE' named entity 'OBSERVED' named entity 'NEUTROPHIL MIGRATION' named entity 'THESE' named entity 'MICE' named entity 'LIMITING' named entity 'ACCOMPANYING' named entity 'MODULATING' named entity 'SPECIFIC' named entity 'REVEALED' named entity 'IS A' named entity 'NUMBER OF' named entity 'NOTABLE' named entity 'CHARACTERIZATION' named entity 'ELEVATED' named entity 'EXAMINED' named entity 'PROTEIN FAMILY' named entity 'WHEY ACIDIC PROTEIN' named entity 'PROVIDE' named entity 'DRAINING' named entity 'NEUTROPHILS'

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