About: A case series of Novel-Coronavirus infection in heart transplantation from two centers in the pandemic area in the North of Italy

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A case series of Novel-Coronavirus infection in heart transplantation from two centers in the pandemic area in the North of Italy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A case series of Novel-Coronavirus infection in heart transplantation from two centers in the pandemic area in the North of Italy
Creator	De Ferrari, Gaetano, Maria Barbero, Cristina Boffini, Massimo Fontana, Alessandra Iacovoni, Attilio Pidello, Stefano Rinaldi, Mauro Sebastiani, Roberta Simonato, Erika Terzi, Amedeo Vittori, Claudia De Ferrari, Maria
Source	Elsevier; Medline; PMC
abstract	BACKGROUND Little is known about the coronavirus SARS-CoV-2 disease (COVID-19) in solid organ transplanted patients. We here report a series of heart transplanted patients with COVID-19 from two centers of Italy. METHODS All heart transplanted patients of Transplant Centers of Bergamo and Torino with a microbiologically confirmed SARS-CoV-2 infection were enrolled. Data collection included clinical presentation, laboratory and radiological findings, treatment and outcome. Follow-up was performed by visit or phone. RESULTS From February to March 2020 twenty-six heart transplanted patients (age 62±12 years; 77% males; time from transplant 10±10 years; 69% with comorbidities) had a microbiologically confirmed COVID-19. The most frequent symptom was fever, followed by cough. Seventeen patients had a pneumonia, 8 of them severe pneumonia. Seven patients died (27%) and 17 (65%) were hospitalized. Discontinuation of immunosuppression was associated with death (71 vs 21%, p=0.02). Conversely, all patients receiving steroids survived (p<0.001). Patients who received heart transplantation during COVID-19 outbreak survived and no acute graft rejection occurred. Patients who died were older than survivors, had a longer time from transplant and a worse clinical presentation at diagnosis. The current regimen enabled the prolonged survival and function of orthotopic cardiac xenografts in altogether 6 of 8 baboons, of which 4 were now added. These results exceed the threshold set by the Advisory Board of the International Society for Heart and Lung Transplantation. CONCLUSIONS COVID-19 has a significant impact on long term heart transplanted patients. Conversely, SARS-CoV-2 infection seems to have a limited influence on more recent transplants. Our experience may suggest that heart transplantation programs can be maintained even during the pandemic phase if specific and tailored paths to prevent and to limit virus transmission are provided.
has issue date	2020-06-26(xsd:dateTime)
bibo:doi	10.1016/j.healun.2020.06.016
bibo:pmid	32709482
has license	no-cc
sha1sum (hex)	ec200f8d772909871e77c67337cc96d8de6a1e3a
schema:url	https://doi.org/10.1016/j.healun.2020.06.016
resource representing a document's title	A case series of Novel-Coronavirus infection in heart transplantation from two centers in the pandemic area in the North of Italy
has PubMed Central identifier	PMC7318961
has PubMed identifier	32709482
schema:publication	J Heart Lung Transplant
resource representing a document's body	covid:ec200f8d772909871e77c67337cc96d8de6a1e3a#body_text
is schema:about of	named entity 'Word count' named entity 'Journal' named entity 'Italy' named entity 'Journal of Heart and Lung Transplantation' named entity 'Immunosuppressive treatment' named entity 'heart transplantation' named entity 'COVID' named entity 'ICU' named entity 'trough levels' named entity 'ICU' named entity 'SARS-CoV-2' named entity 'mycophenolate' named entity 'follow-up' named entity 'immunosuppression' named entity 'pharmacological treatment' named entity 'SARS-CoV-2' named entity 'clinical characteristics' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'mortality rate' named entity 'severe pneumonia' named entity 'procalcitonin' named entity 'Immunosuppressed' named entity 'cubic millimetre' named entity 'catheterization' named entity 'infection' named entity 'heart transplanted' named entity 'immunosuppressive therapy' named entity 'infection' named entity 'prognosis' named entity 'respiratory rate' named entity 'outpatient clinic' named entity 'fever' named entity 'SARS-CoV-2' named entity 'chronic kidney disease' named entity 'Heart Transplant' named entity 'infection' named entity 'COVID' named entity '21 days' named entity 'infection' named entity 'Cyclosporin' named entity 'immunosuppressive agent' named entity 'comorbidity' named entity 'dyspnea' named entity 'COVID-19' named entity 'procalcitonin' named entity 'cough' named entity 'infection' named entity 'comorbidities' named entity 'COVID-19 outbreak' named entity 'infectious disease' named entity 'China' named entity 'adverse outcome' named entity 'CT 17' named entity 'North of Italy' named entity 'heart transplant' named entity 'side-effects' named entity 'Italian' named entity 'chronic kidney disease' named entity 'COVID' named entity 'epidemic' named entity 'severe pneumonia' named entity 'gastro-intestinal' named entity 'oxygen saturation' named entity 'infection' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'adverse events' named entity 'clinical data'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software