About: Detection of dicistroviruses RNA in blood of febrile Tanzanian children

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About: Detection of dicistroviruses RNA in blood of febrile Tanzanian children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of dicistroviruses RNA in blood of febrile Tanzanian children
Creator	Kaiser, Laurent Tapparel, Caroline Cordey, Samuel Junier, Thomas Docquier, Mylène Eibach, Daniel May, Jürgen Brito, Francisco Aldrich, Cassandra Boillat-Blanco, Noémie Hartley, Mary-Anne Kagoro, Frank Keitel, Kristina Laubscher, Florian Lusingu, John Mbarack, Zainab Mlaganile, Tarsis Samaka, Josephine Sothmann, Peter Vieille, Gael D'acremont, Valérie Pérez-Rodriguez, Francisco
topic	covid:ec0528e8df97c81c3e94673e83bf614c09090cf1#this
Source	Medline; PMC
abstract	Fever is the leading cause of paediatric outpatient consultations in Sub-Saharan Africa. Although most are suspected to be of viral origin, a putative causative pathogen is not identified in over a quarter of these febrile episodes. Using a de novo assembly sequencing approach, we report the detection (15.4%) of dicistroviruses (DicV) RNA in sera collected from 692 febrile Tanzanian children. In contrast, DicV RNA was only detected in 1/77 (1.3%) plasma samples from febrile Tanzanian adults, suggesting that children could represent the primary susceptible population. Estimated viral load by specific quantitative real-time RT–PCR assay ranged from < 1.32E3 to 1.44E7 viral RNA copies/mL serum. Three DicV full-length genomes were obtained, and a phylogenetic analyse on the capsid region showed the presence of two clusters representing tentative novel genus. Although DicV-positive cases were detected throughout the year, a significantly higher positivity rate was observed during the rainy season. This study reveals that novel DicV RNA is frequently detected in the blood of Tanzanian children, paving the way for further investigations to determine if DicV possibly represent a new agent in humans.
has issue date	2019-04-19(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1603791
bibo:pmid	30999808
has license	cc-by
sha1sum (hex)	ec0528e8df97c81c3e94673e83bf614c09090cf1
schema:url	https://doi.org/10.1080/22221751.2019.1603791
resource representing a document's title	Detection of dicistroviruses RNA in blood of febrile Tanzanian children
has PubMed Central identifier	PMC6493270
has PubMed identifier	30999808
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:ec0528e8df97c81c3e94673e83bf614c09090cf1#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ec0528e8df97c81c3e94673e83bf614c09090cf1
is schema:about of	named entity 'collected' named entity 'susceptible' named entity 'Three' covid:arg/ec0528e8df97c81c3e94673e83bf614c09090cf1 named entity 'VIRAL RNA' named entity 'VIRAL' named entity 'VIRAL LOAD' named entity 'LENGTH' named entity 'COULD REPRESENT' named entity 'FEVER' named entity 'DE NOVO' named entity 'ESTIMATED' named entity 'ORIGIN' named entity 'SERUM' named entity 'OUTPATIENT' named entity 'CAPSID' named entity 'PAEDIATRIC' named entity 'CONTRAST' named entity 'SUSCEPTIBLE POPULATION' named entity 'QUARTER' named entity 'DETECTION' named entity 'REAL-TIME RT-PCR' named entity 'RNA' named entity 'OBTAINED' named entity 'USING' named entity 'SEQUENCING' named entity 'HIGHER' named entity 'RT-PCR ASSAY' named entity 'REGION' named entity 'GENOMES' named entity 'COLLECTED' named entity 'NOT IDENTIFIED' named entity 'RAINY SEASON' named entity 'YEAR' named entity 'DETECTED' named entity 'SERA' named entity 'LEADING' named entity 'FEBRILE' named entity '692' named entity 'PRESENCE OF' named entity 'RNA' named entity 'IN BLOOD' named entity 'PRIMARY' named entity 'PATHOGEN' named entity 'SUSPECTED' named entity 'APPROACH' named entity 'THESE' named entity 'POSITIVE' named entity 'ASSEMBLY' named entity 'ADULTS' named entity 'EPISODES' named entity 'COPIES' named entity 'PLASMA' named entity 'FEBRILE' named entity 'DETECTION' named entity 'SPECIFIC' named entity 'CONSULTATIONS' named entity 'NOVEL'

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