About: Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread

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About: Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread
Creator	Li, Qingxue Cohen, Jeffrey Ali, Mir
Source	Elsevier; Medline; PMC
abstract	Summary Varicella-zoster virus (VZV) causes chickenpox and shingles. While varicella is likely spread as cell-free virus to susceptible hosts, the virus is transmitted by cell-to-cell spread in the body and in vitro. Since VZV glycoprotein E (gE) is essential for virus infection, we postulated that gE binds to a cellular receptor. We found that insulin-degrading enzyme (IDE) interacts with gE through its extracellular domain. Downregulation of IDE by siRNA, or blocking of IDE with antibody, with soluble IDE protein extracted from liver, or with bacitracin inhibited VZV infection. Cell-to-cell spread of virus was also impaired by blocking IDE. Transfection of cell lines impaired for VZV infection with a plasmid expressing human IDE resulted in increased entry and enhanced infection with cell-free and cell-associated virus. These studies indicate that IDE is a cellular receptor for both cell-free and cell-associated VZV.
has issue date	2006-10-20(xsd:dateTime)
bibo:doi	10.1016/j.cell.2006.08.046
bibo:pmid	17055432
has license	els-covid
sha1sum (hex)	eba30aa66abb1e20a5e265b63f94c6734c909c93
schema:url	https://doi.org/10.1016/j.cell.2006.08.046
resource representing a document's title	Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread
has PubMed Central identifier	PMC7125743
has PubMed identifier	17055432
schema:publication	Cell
resource representing a document's body	covid:eba30aa66abb1e20a5e265b63f94c6734c909c93#body_text
is schema:about of	named entity 'MEDIATING' named entity 'infection' named entity 'body' named entity 'extracted' named entity 'shingles' named entity 'susceptible' named entity 'virus' named entity 'CELLULAR' named entity 'HUMAN' named entity 'IMPAIRED' named entity 'VIRUS' named entity 'CAUSES' named entity 'CELL' named entity 'PROTEIN ' named entity 'SOLUBLE' named entity 'VZV INFECTION' named entity 'BINDS' named entity 'LIKELY' named entity 'VIRUS INFECTION' named entity 'ESSENTIAL' named entity 'LIVER' named entity 'ASSOCIATED VIRUS' named entity 'STUDIES' named entity 'INFECTION' covid:arg/eba30aa66abb1e20a5e265b63f94c6734c909c93 named entity 'ENHANCED' named entity 'CELL' named entity 'CELLULAR' named entity 'IN VITRO' named entity 'TRANSFECTION' named entity 'SUSCEPTIBLE' named entity 'PLASMID' named entity 'RECEPTOR' named entity 'DOWNREGULATION' named entity 'ANTIBODY' named entity 'HOSTS' named entity 'VARICELLA-ZOSTER VIRUS' named entity 'EXTRACTED' named entity 'INSULIN' named entity 'ENZYME' named entity 'CHICKENPOX' named entity 'ENTRY' named entity 'TRANSMITTED BY' named entity 'SPREAD' named entity 'BLOCKING' named entity 'IS A' named entity 'INSULIN-DEGRADING ENZYME' named entity 'BODY' named entity 'CELL LINES' named entity 'SPREAD' named entity 'VARICELLA' named entity 'THESE' named entity 'ITS' named entity 'BACITRACIN' named entity 'IDE' named entity 'IS A' named entity 'RECEPTOR' named entity 'VARICELLA-ZOSTER VIRUS INFECTION' named entity 'SIRNA' named entity 'FREE' named entity 'INHIBITED' named entity 'VZV' named entity 'EXTRACELLULAR DOMAIN' named entity 'INCREASED' named entity 'FOUND' named entity 'GLYCOPROTEIN' named entity 'SHINGLES' named entity 'human' named entity 'postulated' named entity 'Downregulation' named entity 'Varicella-zoster virus' named entity 'antibody' named entity 'Since' named entity 'IDE' named entity 'virus' named entity 'cellular receptor' named entity 'extracellular domain' named entity 'virus' named entity 'cell lines'

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