About: Relationship of α2‐Macroglobulin with Steroid‐Induced Femoral Head Necrosis: A Chinese Population‐Based Association Study in Southeast China

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About: Relationship of α2‐Macroglobulin with Steroid‐Induced Femoral Head Necrosis: A Chinese Population‐Based Association Study in Southeast China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Relationship of α2‐Macroglobulin with Steroid‐Induced Femoral Head Necrosis: A Chinese Population‐Based Association Study in Southeast China
Creator	Chen, Peng Li, Yong-Feng Fang, Shan-Hong Jiang, Jia-Run
Source	Medline; PMC
abstract	OBJECTIVE: The present study aimed to identify the relationship of α‐2‐macroglobulin and microvascular vessel pathology with steroid‐induced femoral head necrosis in the Southeast Chinese population. METHODS: This study enrolled 40 patients diagnosed with steroid‐induced necrosis of the femoral head. Patients had various stages of femoral head necrosis. The differential expression of serum proteins and mRNA from patients with steroid‐induced necrosis of the femoral head (SINFH) and healthy volunteers was analyzed by western blot and quantitative polymerase chain reaction (QT‐PCR). The pathological change in osteocyte necrosis was indicated by hematoxylin and eosin stain and immunohistochemistry. RESULTS: Hematoxylin and eosin stain showed histopathology changes in the necrotic area of patients with steroid‐induced INFH: bone trabeculae were fewer and thinner, became broken, fragmented and structurally disordered; intraosseous adipose cells became enlarged; the arrangement of the osteoblasts became irregular; and vacant bone lacunae increased. QT‐PCR showed significantly lower levels of α‐2‐macroglobulin in the serum of patients with SINFH than in controls (P < 0.05). Immunohistochemical staining and western blotting demonstrated that the expression of α‐2‐macroglobulin was significantly decreased in the necrotic area of SINFH patients (P < 0.05). CONCLUSION: The α‐2‐macroglobulin may be associated with the pathology of SINFH. The multiple pathological reactions occur in SINFH and α‐2‐macroglobulin may serve as a potential biomarker for the diagnosis of SINFH or a promising therapeutic target.
has issue date	2019-06-26(xsd:dateTime)
bibo:doi	10.1111/os.12492
bibo:pmid	31243924
has license	cc-by
sha1sum (hex)	eba0fa2089d19236b36e5b786c1d60e1d083f738
schema:url	https://doi.org/10.1111/os.12492
resource representing a document's title	Relationship of α2‐Macroglobulin with Steroid‐Induced Femoral Head Necrosis: A Chinese Population‐Based Association Study in Southeast China
has PubMed Central identifier	PMC6595108
has PubMed identifier	31243924
schema:publication	Orthop Surg
resource representing a document's body	covid:eba0fa2089d19236b36e5b786c1d60e1d083f738#body_text
is schema:about of	named entity 'NECROSIS' named entity 'INDUCED' named entity 'identify' named entity 'Chinese' named entity 'ASSOCIATION STUDY' named entity 'STEROID' named entity 'STEROID-INDUCED FEMORAL HEAD NECROSIS' named entity 'CHINA' named entity 'B12' named entity 'STUDY' named entity 'TO IDENTIFY' named entity 'SOUTHEAST' named entity 'CHINESE' named entity 'CHINESE' named entity 'SOUTHEAST' named entity 'POPULATION' named entity 'MICROVASCULAR' named entity 'PRESENT' named entity 'OBJECTIVE' named entity 'VESSEL' named entity 'RELATIONSHIP' named entity 'PATHOLOGY' named entity 'MACROGLOBULIN' named entity 'POPULATION-BASED' named entity 'RELATIONSHIP' named entity 'FEMORAL HEAD' named entity 'MACROGLOBULIN' covid:arg/eba0fa2089d19236b36e5b786c1d60e1d083f738 named entity 'necrosis' named entity 'Necrosis' named entity 'Femoral Head' named entity 'protein' named entity 'osteosclerosis' named entity 'femoral head' named entity 'stage III' named entity 'α2-macroglobulin' named entity 'femoral head' named entity 'α2-macroglobulin' named entity 'intravascular coagulation' named entity 'gene' named entity 'μCT' named entity 'MMP' named entity 'lacunae' named entity 'hydrolysis' named entity 'stage IV' named entity 'ischemic' named entity 'heterogeneity' named entity 'phosphate buffered saline' named entity 'fat cells' named entity 'femoral head' named entity 'serum' named entity 't-test' named entity 'cartilage' named entity 'MRI' named entity 'F-actin' named entity 'subchondral' named entity 'inflammation' named entity 'α2-macroglobulin' named entity 'femoral head' named entity 'adipose cells' named entity 'serum level' named entity 'serum samples' named entity 'Carlsbad, CA' named entity 'plasmin' named entity 'streptavidin' named entity 'thromboembolic events' named entity 'α2-macroglobulin' named entity 'therapeutic target' named entity 'femoral head' named entity 'general anesthesia' named entity 'osteonecrosis' named entity 'MMP' named entity 'hip joint' named entity 'cell nuclei' named entity 'superoxide dismutase' named entity 'Declaration of Helsinki' named entity 'binding sites' named entity 'Germany'

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