About: Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4

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About: Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4
Creator	Hoffman, P Weber, K Anderton, B Ayers, M Bignami, A Biserte, G Boutteau, F Bullock, C Dahl, D Delacourte, A Farr, A Filliatreau, G Fluegge, G Komiya, Y Kurokawa, M Lasek, R Lett ; Debus, E Liem, R Mori, H Osborn, M Randall, R Rosebrough, N Rueger, D Salomon, G Sharp, G Shaw, G Shelanski, M Simon, C Willard, M Yen, S.-H Yokoyama, K
Source	Medline; PMC
abstract	Mouse hepatitis virus type 4 (MHV-4, the JHM strain), a positive-strand RNA virus of the coronavirus family, is well documented as an inducer of acute(1–4) and chronic(5,6) demyelination in mice, as well as subacute demyelination in rats(7,8), due to a cytolytic infection of oligodendrocytes(3,4,7). However, experiments to explore the role of virus and host factors in the production of chronic or recurrent demyelinating disease have been limited because MHV-4 usually produces demyelination in conditions that frequently induce a fatal necrotizing encephalomyelitis(1–9). To circumvent this problem, we had made and selected mutant viruses that caused both a high incidence of demyelination and a low incidence of encephalitis-induced mortality(9). One such mutant, designated ts8, consistently caused acute demyelinating disease in over 90% of intracerebrally or intranasally (natural route of infection) inoculated, 4–5 week-old mice from several susceptible strains within 6–10 days(9,10). In addition, ts8 typically did not cause fatal necrotizing encephalitis, showing a low mortality (<5%)(9,10). This reflected a unique tropism of ts8 for oligodendrocytes, but a limited one for neuronal cells(11). We now report that ts8 is also useful for inducing persistent infection of the mouse central nervous system (CNS). The histopathological correlate of this infection is chronic recurrent demyelination, and virus can be demonstrated ultrastructurally in intact oligodendrocytes, in the vicinity of demyelinated areas.
has issue date	1982-01-01(xsd:dateTime)
bibo:doi	10.1038/298279a0
bibo:pmid	6283382
has license	no-cc
sha1sum (hex)	eb96d498bb92cd3a4a99048987744fcc6bab50ea
schema:url	https://doi.org/10.1038/298279a0
resource representing a document's title	Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of MHV-4
has PubMed Central identifier	PMC7095068
has PubMed identifier	6283382
schema:publication	Nature
resource representing a document's body	covid:eb96d498bb92cd3a4a99048987744fcc6bab50ea#body_text
is schema:about of	named entity 'surface' named entity 'produced' named entity 'SURFACE' named entity 'NEUROFILAMENTS' named entity 'ATTRIBUTES' named entity 'PHYSIOLOGICAL' named entity 'RESULTS' named entity 'DISPOSITION' named entity 'NEURONAL' named entity 'COMPONENTS' named entity 'DEMYELINATION' named entity 'INTERACTING' named entity 'NOT NEEDED' named entity 'FUNCTION' named entity 'POSSIBLY' named entity 'CELLULAR' named entity 'ABSENCE OF' named entity 'PRESENTED' named entity 'RECURRING' named entity 'PERFORMED BY' named entity 'PERIPHERAL' named entity 'POSSIBLE' named entity 'ROLE' named entity 'VIRUS PERSISTENCE' named entity 'HERE' named entity 'TEMPERATURE-SENSITIVE' named entity 'MHV-4' named entity 'NEURONES' named entity 'PROTEIN ' named entity 'NEUROFILAMENT' named entity 'MUTANT' named entity 'MORPHOLOGICAL' named entity 'ALL STAGES' named entity 'PRESENCE' named entity 'DEVELOPMENT' named entity 'PARTICULAR' named entity 'REQUIRED' named entity 'DYNAMICS' covid:arg/eb96d498bb92cd3a4a99048987744fcc6bab50ea named entity 'neurofilaments' named entity 'correlate' named entity 'presence' named entity 'presented' named entity 'disposition' named entity 'neuronal' named entity 'neurofilament' named entity 'demyelination' named entity 'infection' named entity 'remyelination' named entity 'host factors' named entity 'experimental evidence'

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