About: Impact of routine infant BCG vaccination in young generation on prevention of local COVID-19 spread in Japan

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About: Impact of routine infant BCG vaccination in young generation on prevention of local COVID-19 spread in Japan Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of routine infant BCG vaccination in young generation on prevention of local COVID-19 spread in Japan
Creator	Kinoshita, Masako Tanaka, Masami
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: In Japan, the first case of coronavirus disease 2019 (COVID-19) was diagnosed on January 15, 2020 and subsequent infections rapidly increased. The Bacillus Calmette-Guérin (BCG) vaccination program is the principal element of tuberculosis control in Japan. We investigated the impact of routine infant BCG vaccination on prevention of local COVID-19 spread. METHODS: Data on the prevalence of SARS-CoV-2 infection, annual routine infant BCG vaccine coverage (represented by the number of BCG vaccinations per live births), and other candidate factors in each prefecture were obtained from the official notifications database in Japan. We analysed the association of vaccine coverage with the prevalence of SARS-CoV-2 infection. RESULTS: The BCG vaccine coverage in 1999–2002, 2004, and 2012 in five prefectures with no COVID-19 infections was significantly higher than that in five prefectures with a high prevalence of infections (Mann-Whitney U test, p<0.05). The prevalence of SARS-CoV-2 infection was significantly negatively correlated with BCG vaccine coverage in 2004 and was significantly positively correlated with age groups 20–34 and 40–54 years (Spearman's rank correlation, p<0.01). CONCLUSIONS: Our findings suggest that routine infant BCG vaccination coverage in young generation had a significant impact on prevention of local COVID-19 spread in Japan.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2020.08.013
bibo:pmid	32795481
has license	no-cc
sha1sum (hex)	eb296f8d392e7dbbcb226d41f8706e7ea7c0442f
schema:url	https://doi.org/10.1016/j.jinf.2020.08.013
resource representing a document's title	Impact of routine infant BCG vaccination in young generation on prevention of local COVID-19 spread in Japan
has PubMed Central identifier	PMC7419263
has PubMed identifier	32795481
schema:publication	J Infect
resource representing a document's body	covid:eb296f8d392e7dbbcb226d41f8706e7ea7c0442f#body_text
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