About: Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
Creator	Yousefi, Mehdi Esposito, Silvano Pagliano, Pasquale Kafil, Hossein Ganbarov, Khudaverdi Gholizadeh, Pourya Khodadadi, Ehsaneh Marofi, Parham Safari, Rohollah Zeinalzadeh, Elham
source	Medline; PMC
abstract	INTRODUCTION: Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. PATIENTS AND METHODS: We recruited 279 patients who confirmed COVID-19 and the data of liver biomarkers and complete blood count of patients were defined as the day onset when the patients admitted to the hospital. RESULTS: The average of LDH value was 621.29 U/L in all patients with COVID-19, and CPK was 286.90 U/L. The average AST was 44.03 U/L in all patients, and ALT was 31.14 U/L. The AST/ALT ratio was 1.64 in all patients. The measurement of CRP was increased by 79.93% in all patients. Average ALT and AST values of patients with elevated ALT were significantly increased in comparison to patients with normal ALT (P-value = 0.001), while AST/ALT ratio was significantly decreased compared to patients with normal ALT (P-value= 0.014). In addition, the average LDH of patients with elevated ALT was significantly increased compared to patients with normal ALT (P-value = 0.014). CONCLUSION: Hepatic injury and abnormal liver enzymes related to COVID-19 infection is an acute non-specific inflammation alteration.
has issue date	2020-07-01(xsd:dateTime)
bibo:doi	10.2147/jir.s257078
bibo:pmid	32669866
has license	cc-by-nc
sha1sum (hex)	eb23bd37d01999d43d67289ea21a50de2a7a9476
schema:url	https://doi.org/10.2147/jir.s257078
resource representing a document's title	Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
has PubMed Central identifier	PMC7335895
has PubMed identifier	32669866
schema:publication	J Inflamm Res
resource representing a document's body	covid:eb23bd37d01999d43d67289ea21a50de2a7a9476#body_text
is schema:about of	named entity 'ELEVATED ALT' named entity 'ACUTE' named entity 'AVERAGE' named entity 'ALT' named entity 'VALUE' named entity 'RATIO' covid:arg/eb23bd37d01999d43d67289ea21a50de2a7a9476 named entity 'Hepatic' named entity 'LDH' named entity 'COVID' named entity 'significantly increased' named entity 'infection' named entity 'Biomarkers' named entity 'viral infections' named entity 'COVID' named entity 'liver' named entity 'caused by COVID-19' named entity 'viruses' named entity 'organ' named entity 'AST' named entity 'COVID' named entity 'supportive therapy' named entity 'health problems' named entity 'aspartate transaminase' named entity 'bat' named entity 'CRP' named entity 'COVID-19' named entity 'alanine aminotransferase' named entity 'Liver dysfunction' named entity 'ATS' named entity 'liver enzymes' named entity 'biomarkers' named entity 'LDH' named entity 'antigens' named entity 'LDH' named entity 'risk factors' named entity 'AST' named entity 'PDW' named entity 'SARS' named entity 'COVID' named entity 'AST' named entity 'COVID-19' named entity 'elevation of liver enzymes' named entity 'lactate dehydrogenase' named entity 'crackles' named entity 'hematocrit' named entity 'antigens' named entity 'COVID' named entity 'antiviral' named entity 'single-stranded' named entity 'chest CT' named entity 'fever' named entity 'Viral' named entity 'gamma-glutamyl transferase' named entity 'WBC' named entity 'SARS-like coronaviruses' named entity 'radiology' named entity 'red blood cell' named entity 'hydroxychloroquine' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'avian flu' named entity 'lopinavir/ritonavir' named entity 'HEV' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'Tabriz' named entity 'red blood cell' named entity 'hepatic insufficiency' named entity 'excessive alcohol consumption' named entity 'infection' named entity 'hepatic injury' named entity 'coronavirus disease 2019'

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