About: Immunity to PRRSV: Double-edged sword

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunity to PRRSV: Double-edged sword
Creator	Choi, C Molitor, T Bautista, E
Source	Elsevier; Medline; PMC
abstract	Abstract The immune system is a double-edged sword for porcine reproductive and respiratory syndrome virus (PRRSV) infection. On one edge PRRSV has a predilection for immune cells and the disease manifestations can be linked directly to changes in the immune system. PRRSV appears to replicate extensively, if not exclusively, in cells of the immune lineage, notably macrophages; the direct replication of which may lead to immunosuppression, precipitate secondary infection and/or mediate disease. On the other edge, the virus stimulates immunity post-infection that protects an animal from re-infection. A vast array of structural and functionally distinct antibody specific to PRRSV are generated following infection or vaccination. Discrete populations of functional antibodies appear at different times and possibly reflect reactivity to different PRRSV polypeptides. Cell-mediated immune responses specific to PRRSV can be detected in various exposed pigs as well. Thus, the immune system appears to be intimately involved in both the disease process and protection from disease. It is unclear at this state of understanding what immune compartment provides protective immunity. Is it humoral (i.e. antibodies), selective functionally distinct populations of antibodies specific for selected PRRSV polypeptides or is cellular immunity essential for protection, or both. This review will attempt to summarize the current state of knowledge of the complex interaction of the immune system and PRRSV.
has issue date	1997-04-30(xsd:dateTime)
bibo:doi	10.1016/s0378-1135(96)01327-2
bibo:pmid	9220622
has license	els-covid
sha1sum (hex)	eacc051c2ef171b61db776f494f774cbaf8f264a
schema:url	https://doi.org/10.1016/s0378-1135%2896%2901327-2
resource representing a document's title	Immunity to PRRSV: Double-edged sword
has PubMed Central identifier	PMC7117121
has PubMed identifier	9220622
schema:publication	Veterinary Microbiology
resource representing a document's body	covid:eacc051c2ef171b61db776f494f774cbaf8f264a#body_text
is schema:about of	named entity 'DOUBLE' named entity 'polypeptides' named entity 'immunity' named entity 'secondary infection' named entity 'IMMUNE' named entity 'APPEAR' named entity 'EDGE' covid:arg/eacc051c2ef171b61db776f494f774cbaf8f264a named entity 'FOLLOWING' named entity 'PRECIPITATE' named entity 'DISTINCT' named entity 'ANTIBODY' named entity 'SWORD' named entity 'DISCRETE' named entity 'SECONDARY INFECTION' named entity 'GENERATED' named entity 'VACCINATION' named entity 'CHANGES' named entity 'ANIMAL' named entity 'POSSIBLY' named entity 'IMMUNITY' named entity 'SWORD' named entity 'PRRSV' named entity 'IMMUNITY' named entity 'LEAD' named entity 'STRUCTURAL' named entity 'INFECTION' named entity 'SPECIFIC' named entity 'MEDIATE' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'REPLICATION' named entity 'DIFFERENT' named entity 'IMMUNOSUPPRESSION' named entity 'DIRECTLY' named entity 'TIMES' named entity 'IMMUNE CELLS' named entity 'POLYPEPTIDES' named entity 'VIRUS' named entity 'REFLECT' named entity 'DOUBLE' named entity 'DISEASE' named entity 'ANTIBODIES' named entity 'REACTIVITY' named entity 'IS A' named entity 'LINEAGE' named entity 'POST' named entity 'MACROPHAGES' named entity 'REPLICATE' named entity 'POPULATIONS' named entity 'CELLS' named entity 'DIRECT' named entity 'IMMUNE SYSTEM' named entity 'ARRAY' named entity 'MANIFESTATIONS' named entity 'FUNCTIONAL' named entity 'Discrete' named entity 'reactivity' named entity 'replicate' named entity 'precipitate' named entity 'immune cells' named entity 'array' named entity 'animal' named entity 'antibodies' named entity 'infection' named entity 'PRRSV' named entity 'porcine reproductive and respiratory syndrome virus' named entity 'infection' named entity 'PRRSV' named entity 'macrophages' named entity 'immunosuppression' named entity 'PRRSV' named entity 'Double-edged sword' named entity 'lymphocyte' named entity 'virus' named entity 'humoral' named entity 'colostrum' named entity 'Streptococcus suis' named entity 'cellular immunity' named entity 'infection'

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