About: A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors

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About: A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors
Creator	Chu, Shirley Fleer, Maren Wylie, Kristine Bryan, Jeffrey Griffith, L Johnson, Gayle Skidmore, Zachary Wylie, Todd
topic	covid:ea800dcdcf09ab648a3229d2f1e02159877a4f53#this
Source	Elsevier; Medline; PMC
abstract	Feline oral squamous cell carcinoma (FOSCC) may be the best naturally-occurring model of human head and neck squamous cell carcinoma (HNSCC). HNSCC can be broadly divided into human papillomavirus (HPV)-negative cancers and HPV-positive cancers where HPV is the causative agent. Previous studies in FOSCC have used both species-specific and species-nonspecific PCR primers that may be insensitive to the detection of PVs and other viruses that may be divergent from known sequences. ViroCap is a targeted capture and next generation sequencing tool that was designed to identify all known vertebrate DNA and RNA viruses. In this study we used a metagenomic approach using ViroCap for DNA viruses in 20 FOSCC, 9 normal feline oral mucosal, and 8 suspected PV positive control samples. We tested the hypothesis that viruses would be enriched in FOSCC compared to normal oral mucosa. The virome of the FOSCC and normal feline oral mucosa consisted of feline foamy virus in 7/20 and 2/9 (35% and 22%), feline torque teno virus in 2/20 and 0/9 (10% and 0%), alphaherpesvirus in 2/10 and 0/9 (10% and 0%), FIV (0% and 22%), Epstein-Barr virus in 1/20 and 0/9 (5% and 0%) and feline papillomavirus in 1/20 and 0/9 samples (5% and 0% respectively). Felis catus papillomavirus-3 was found in 1 of 20 FOSCC samples. A virus was not associated consistently with FOSCC. If PVs have a role in FOSCC it is at most a supplementary or uncommon role. FOSCC appears most closely related to HPV-negative HNSCC. Future research on FOSCC should focus on identifying genetic and environmental causes.
has issue date	2019-11-02(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.108491
bibo:pmid	31902496
has license	no-cc
sha1sum (hex)	ea800dcdcf09ab648a3229d2f1e02159877a4f53
schema:url	https://doi.org/10.1016/j.vetmic.2019.108491
resource representing a document's title	A virome sequencing approach to feline oral squamous cell carcinoma to evaluate viral causative factors
has PubMed Central identifier	PMC7117531
has PubMed identifier	31902496
schema:publication	Vet Microbiol
resource representing a document's body	covid:ea800dcdcf09ab648a3229d2f1e02159877a4f53#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ea800dcdcf09ab648a3229d2f1e02159877a4f53
is schema:about of	named entity 'FELINE ORAL SQUAMOUS CELL CARCINOMA' named entity 'HNSCC' named entity 'Felis catus' named entity 'identifying' named entity 'focus' named entity 'compared' named entity 'suspected' covid:arg/ea800dcdcf09ab648a3229d2f1e02159877a4f53 named entity 'FELIS CATUS PAPILLOMAVIRUS' named entity 'DIVIDED' named entity 'EPSTEIN-BARR VIRUS' named entity 'HPV' named entity 'HUMAN PAPILLOMAVIRUS ' named entity 'PVS' named entity 'STUDIES' named entity 'SUSPECTED' named entity 'DETECTION' named entity 'GENETIC' named entity 'SEQUENCES' named entity 'SAMPLES' named entity 'NORMAL' named entity 'RESEARCH' named entity 'ORAL MUCOSAL' named entity 'RNA VIRUSES' named entity 'ALPHAHERPESVIRUS' named entity 'DIVERGENT FROM' named entity 'HYPOTHESIS' named entity 'VETERINARY MICROBIOLOGY' named entity 'COMPARED' named entity 'NONSPECIFIC' named entity 'CAUSES' named entity 'IDENTIFYING' named entity 'TARGETED' named entity 'VIRUS' named entity 'VIRAL' named entity 'APPROACH' named entity 'RELATED' named entity 'CAUSATIVE AGENT' named entity 'CAPTURE' named entity 'DNA' named entity 'EVALUATE' named entity 'USED' named entity 'DNA VIRUSES' named entity 'BEST' named entity 'TESTED' named entity 'STUDY' named entity 'FOUND' named entity 'SEQUENCING' named entity 'PREVIOUS' named entity 'KNOWN' named entity 'UNCOMMON' named entity 'MODEL OF' named entity 'FELINE PAPILLOMAVIRUS' named entity 'USING' named entity 'FUTURE' named entity 'MAY BE' named entity 'METAGENOMIC APPROACH' named entity 'CHU' named entity 'NEGATIVE' named entity 'TOOL' named entity 'FIV' named entity 'HNSCC' named entity '1135' named entity 'IS A' named entity 'FELINE' named entity 'PCR PRIMERS' named entity '240' named entity 'ASSOCIATED' named entity 'TORQUE TENO VIRUS' named entity '2F10' named entity 'VIRUSES' named entity 'SPECIES'

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