About: A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry

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About: A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry
Creator	Ren, Xiaofeng Suo, Siqingaowa Cong, Yingying Zhao, Qiong Meng, Fandan Ma, Xiaowei Zarlenga, Dante
Source	Elsevier; Medline; PMC
abstract	Abstract Three phage-displayed peptides designated H, S and F that recognize porcine aminopeptidase N (pAPN), the cellular receptor of porcine transmissible gastroenteritis virus (TGEV) were able to inhibit cell infection by TGEV. These same peptides had no inhibitory effects on infection of Vero cells by porcine epidemic diarrhea virus (PEDV). However, when PEDV, TGEV and porcine pseudorabies virus were incubated with peptide H (HVTTTFAPPPPR), only infection of Vero cells by PEDV was inhibited. Immunofluoresence assays indicated that inhibition of PEDV infection by peptide H was independent of pAPN. Western blots demonstrated that peptide H interacted with PEDV spike protein and that pre-treatment of PEDV with peptide H led to a higher inhibition than synchronous incubation with cells. These results indicate direct interaction with the virus is necessary to inhibit infectivity. Temperature shift assays demonstrated that peptide H inhibited pre-attachment of the virus to the cells.
has issue date	2014-05-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.01.010
bibo:pmid	24889221
has license	els-covid
sha1sum (hex)	ea53bcaf678ee12c0b564f013ae0d7d28b79c5b8
schema:url	https://doi.org/10.1016/j.virol.2014.01.010
resource representing a document's title	A phage-displayed peptide recognizing porcine aminopeptidase N is a potent small molecule inhibitor of PEDV entry
has PubMed Central identifier	PMC7112085
has PubMed identifier	24889221
schema:publication	Virology
resource representing a document's body	covid:ea53bcaf678ee12c0b564f013ae0d7d28b79c5b8#body_text
is schema:about of	named entity 'PORCINE' named entity 'protein' named entity 'cells' named entity 'cells' named entity 'inhibition' named entity 'ENTRY' named entity 'DESIGNATED' named entity 'INCUBATION' named entity 'HIGHER' named entity 'PRETREATMENT' named entity 'INHIBITION' named entity 'PROTEIN ' named entity 'TO INHIBIT' named entity 'INFECTION' named entity 'EFFECTS' covid:arg/ea53bcaf678ee12c0b564f013ae0d7d28b79c5b8 named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PSEUDORABIES VIRUS' named entity 'CELLULAR' named entity 'WESTERN BLOTS' named entity 'AMINOPEPTIDASE N' named entity 'INCUBATED' named entity 'SYNCHRONOUS' named entity 'THESE' named entity 'PEPTIDES' named entity 'PHAGE' named entity 'VERO CELLS' named entity 'PHAGE' named entity 'CELLS' named entity 'RECOGNIZE' named entity 'SPIKE PROTEIN' named entity 'PEPTIDE' named entity 'DISPLAYED' named entity 'AMINOPEPTIDASE N' named entity 'PEDV' named entity 'IS A' named entity 'INHIBITORY' named entity 'RECEPTOR' named entity 'DISPLAYED' named entity 'DEMONSTRATED' named entity 'INTERACTED' named entity 'PEPTIDE' named entity 'INDICATED' named entity 'PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'CELL' named entity 'PORCINE' named entity 'LED' named entity 'INHIBITED' named entity 'SMALL MOLECULE INHIBITOR' named entity 'INDEPENDENT OF' named entity 'porcine' named entity 'However' named entity 'PBS' named entity 'pig' named entity 'small molecule inhibitors' named entity 'PEDV' named entity 'independent' named entity 'peptide' named entity 'inhibition' named entity 'peptide' named entity 'infection' named entity 'porcine' named entity 'incubation' named entity 'peptide' named entity 'peptide' named entity 'PEDV' named entity 'Vero' named entity 'pseudorabies virus' named entity 'infection' named entity 'PEDV' named entity 'transmissible gastroenteritis virus' named entity 'aminopeptidase' named entity 'peptide' named entity 'phage' named entity 'led'

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