About: Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3

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About: Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3
Creator	Wang, Jian Gu, Shao-Hua Ji, Chao-Neng Tang, Hai-Ping Xie, Yi Xu, Wan-Xiang He, Ya-Ping Shi, Hui-Juan Sun, Xiao-Xi
source	Medline; PMC
abstract	The human zona pellucida glycoprotein-3 (hZP3) by virtue of its critical role during fertilization has been proposed as a promising candidate antigen to develop a contraceptive vaccine. In this direction, it is imperative to map minimal motifs of the B cell epitopes (BCEs) so as to avoid ZP-specific oophoritogenic T cell epitopes (TCEs) in the ZP3-based immunogens. In this study, based on known results of mapping marmoset and bonnet monkey ZP3 (mstZP3 and bmZP3), two predictable epitopes(23–30 and 301–320) on hZP3 were first confirmed and five minimal motifs within four epitopes on hZP3 were defined using serum to recombinant hZP3a(22–176) or hZP3b(177–348) as well as a biosynthetic peptide strategy. These defined minimal motifs were QPLWLL(23–28) for hZP3(23–30), MQVTDD(103–108) for hZP3(93–110), EENW(178–181) for hZP3(172–190), as well as SNSWF(306–310) and EGP(313–315) for hZP3(301–320), respectively. Furthermore, the antigenicity of two peptides for hZP3(172–187) and hZP3(301–315) and specificity of the antibody response to these peptides were also evaluated, which produced high-titer antibodies in immunized animals that were capable of reacting to ZP on human oocytes, r-hZP3b(177–348) protein, as well as r-hZP3(172–190), r-hZP3(303–310), and r-hZP3(313–320) epitope peptides fused with truncated GST188 protein.
has issue date	2011-11-17(xsd:dateTime)
bibo:doi	10.1155/2012/831010
bibo:pmid	22162720
has license	cc-by
sha1sum (hex)	ea40bddad18086f300f45b71a07f3e4c14e060eb
schema:url	https://doi.org/10.1155/2012/831010
resource representing a document's title	Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3
has PubMed Central identifier	PMC3227431
has PubMed identifier	22162720
schema:publication	Clin Dev Immunol
resource representing a document's body	covid:ea40bddad18086f300f45b71a07f3e4c14e060eb#body_text
is schema:about of	named entity 'human' named entity 'minimal' named entity 'peptides' named entity 'peptide' named entity 'based' named entity 'Zona' named entity 'Motifs' named entity '178' named entity 'SERUM' named entity 'CRITICAL' named entity '310' named entity 'SPECIFIC' named entity 'PEPTIDES' named entity 'CONTRACEPTIVE VACCINE' named entity 'ZONA PELLUCIDA GLYCOPROTEIN' named entity '108' named entity 'ITS' named entity 'CANDIDATE' named entity 'BASED' named entity 'T CELL' named entity 'ANTIGEN' named entity 'IMMUNOGENS' named entity '313' named entity 'ANIMALS' named entity '348' named entity 'BONNET' named entity 'RECOMBINANT' named entity 'ROLE' named entity 'MAP' named entity '187' named entity 'TO AVOID' named entity 'TITER' named entity 'PROTEIN' named entity 'HUMAN' named entity 'SPECIFICITY' named entity 'MARMOSET' named entity 'DEFINED' named entity 'FUSED WITH' named entity 'IMMUNIZED' named entity 'MONKEY' named entity 'EPITOPES' named entity 'CONFIRMED' named entity 'ANTIBODIES' named entity 'EPITOPES' named entity 'EGP' named entity 'OOCYTES' named entity 'MAPPING' named entity 'STRATEGY' named entity '110' named entity 'KNOWN' named entity '172' named entity 'EPITOPE' named entity 'MOTIFS' named entity 'ZONA PELLUCIDA GLYCOPROTEIN' named entity '103' named entity 'MINIMAL' named entity 'EVALUATED' named entity 'RESPONSE TO' named entity 'STUDY' named entity '320' named entity 'ANTIGENICITY' named entity 'B CELL' named entity 'THESE' named entity 'BIOSYNTHETIC' named entity 'TRUNCATED' named entity 'ANTIBODY RESPONSE' named entity 'PROPOSED' named entity 'USING' named entity 'HUMAN' named entity 'RESULTS' named entity 'DIRECTION' named entity 'CAPABLE' named entity 'MOTIFS'

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