About: Histopathological evaluation of placentas after diagnosis of maternal SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Histopathological evaluation of placentas after diagnosis of maternal SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Histopathological evaluation of placentas after diagnosis of maternal SARS-CoV-2 infection
Creator	Metz, Edelman, Morris Gulersen, Moti Meirowitz, Natalie Metz, Christine Millington, Karmaine Prasannan, Lakha Rochelson, Burton Shan, Weiwei Tam, Hima Tam, Tam
Source	Elsevier; Medline; PMC
abstract	Abstract Background The impact of maternal SARS-CoV-2 infection on placental histopathology is not well known. Objectives To determine if significant placental histopathological changes occur after diagnosis of SARS-CoV-2 infection in pregnancy and whether these changes are correlated with the presence or absence of symptoms associated with infection. Study Design Retrospective cohort study of women diagnosed with SARS-CoV-2 infection who delivered at a single center from April 9th to April 27th, 2020, and had placental specimens reviewed by pathology. Women with singleton gestations and laboratory-confirmed SARS-CoV-2 infection were eligible for inclusion. Historical controls selected from a cohort of women who delivered 6 months prior to the study period were matched in a 1:1 fashion by week of gestation at delivery. Histopathological characteristics were evaluated in each placenta and the incidence of these findings were compared between placentas after diagnosis of maternal SARS-CoV-2 infection and historical controls, as well as between placentas from patients with or without typical symptoms related to infection. Statistical analysis included use of Wilcoxon rank sum test and Fisher’s exact test for comparison of categorical and continuous variables. Statistical significance was defined as P value < 0.05. Results A total of 50 placentas after diagnosis of maternal SARS-CoV-2 infection and 50 historical controls were analyzed. Among placentas from patients diagnosed with SARS-CoV-2 infection, 3 (6%) were preterm (33 3/7, 34 6/7 and 36 6/7 weeks of gestation), 16 (32%) were from patients with typical symptoms related to infection and 34 (68%) were from patients without typical symptoms related to the infection. All patients had diagnosis of SARS-CoV-2 infection in the third trimester. Decidual vasculopathy was not visualized in any of the placentas from patients diagnosed with SARS-CoV-2 infection. There was no statistically significant difference in placental histopathological characteristics between the groups. SARS-CoV-2 testing for all neonates at 24 hours of life was negative. Conclusions Based on our data, there are no significant placental histopathological changes that occur after diagnosis of SARS-CoV-2 infection in the third trimester of pregnancy compared to a gestational age-matched historical control group. Similar incidences of histopathological findings were also discovered when comparing placentas from patients with SARS-CoV-2 infection with or without the presence of symptoms typically related to infection.
has issue date	2020-08-15(xsd:dateTime)
bibo:doi	10.1016/j.ajogmf.2020.100211
bibo:pmid	32838277
has license	els-covid
sha1sum (hex)	e9b6249943d2c51ff68dc6c7a9991981f65556b5
schema:url	https://doi.org/10.1016/j.ajogmf.2020.100211
resource representing a document's title	Histopathological evaluation of placentas after diagnosis of maternal SARS-CoV-2 infection
has PubMed Central identifier	PMC7428686
has PubMed identifier	32838277
schema:publication	Am J Obstet Gynecol MFM
resource representing a document's body	covid:e9b6249943d2c51ff68dc6c7a9991981f65556b5#body_text
is schema:about of	named entity 'Condensation' named entity 'Epub' named entity 'More' named entity 'infection' named entity 'symptoms' named entity 'SARS-CoV-2' named entity 'Main' named entity 'histopathological' named entity 'diagnosis' named entity 'presentations' named entity 'Baptiste' named entity 'Abstract' named entity 'Pregnancy' named entity 'Title 5' named entity 'placental' named entity 'weeks' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Pregnancy' named entity 'SARS-CoV-2' named entity 'infection' named entity 'Histopathological' named entity 'placental' named entity 'neonates' named entity 'respiratory disease' named entity 'staining' named entity 'Northwell Health' named entity 'infection' named entity 'SARS-CoV-2' named entity 'case series' named entity 'fetal development' named entity 'infection' named entity 'histopathological' named entity 'Fisher's exact test' named entity 'Institutional Review' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'confounders' named entity 'Placental' named entity 'SARS-CoV-2' named entity 'sampling' named entity 'decidual' named entity 'placental' named entity 'infection' named entity 'New York' named entity 'vasculopathy' named entity 'race/ethnicity' named entity 'infection' named entity 'infection' named entity 'malperfusion' named entity 'SARS-CoV-2' named entity 'histopathological' named entity 'significant difference' named entity 'peripartum' named entity 'histopathological' named entity 'Queens' named entity 'infection' named entity 'SARS' named entity 'oxygen saturation' named entity 'chorangiosis' named entity 'antepartum' named entity 'birthweight' named entity 'staining' named entity 'retrospective cohort study' named entity 'SARS-CoV-2' named entity 'dyspnea' named entity 'polymerase chain reaction' named entity 'informed consent' named entity 'Long Island' named entity 'histopathological' named entity 'vertical transmission'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software