About: Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report
Creator	Egan, Michael Francisco, San Gold, Michael Kosco-Vilbois, Marie Swanson, Chad Weiner, M Abushakra, Susan Aisen, P Alam, John Andrieu, Sandrine Bansal, Anu Baudler, Monika Bell, Joanne Beraud, Mickaël Bittner, Tobias Budd, Samantha Bullain, Szofia Cantillon, Marc Carrillo, Maria Castrillo-Viguera, Carmen Cheung, Ivan Christian, ) Coelho, Julia Cummings, J Detke, M Di, Daniel Doody, Rachelle Dwyer, John Ewen, Colin Fisher, Charles Gauthier, Serge Gauthier, S Gilbert, ( Gilles, ) Haichen, ; Hampel, Harald Hehn, Von Keeley, Michael Kerchner, Geoffrey Kinney, Gene Kolb, Hartmuth Kramer, Lynn Kurzman, Ricky Lake, Woodcliff Lannfelt, Lars Lawson, John Li, Jinhe Longo, F Marcos, San Mintun, Mark Navikas, Vaidrius Novak, Gerald Olivier, ) Osswald, Gunilla Ostrowitzki, Susanne Porsteinsson, Anton Raman, R Rubino, Ivana Sabbagh, M Salloway, Stephen San, South Schindler, Rachel Schneider, L Sekiya, Hiroshi Selkoe, Dennis Siemers, Eric Sims, John Sipe, Lisa Sperling, Reisa Stephens, Andrew Streffer (braine-L', Johannes Suhy, Joyce Tanzi, R Tariot, P Teng, Edmond Tolar, Martin Traber, Martin Vergallo, Andrea Vradenburg, George Wagner, ; Walker, Judy Wunderlich, Glen Yaari, Roy Zoda, Thomas
Source	PMC
abstract	While amyloid-targeting therapies continue to predominate in the Alzheimer’s disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as well. In December 2019, The EU/US CTAD Task Force discussed these alternative approaches to disease modification in AD, focusing on tau-targeting therapies, neurotrophin receptor modulation, anti-microbial strategies, and the innate immune response; as well as vascular approaches, aging, and non-pharmacological approaches such as lifestyle intervention strategies, photobiomodulation and neurostimulation. The Task Force proposed a general strategy to accelerate the development of alternative treatment approaches, which would include increased partnerships and collaborations, improved trial designs, and further exploration of combination therapy strategies.
has issue date	2020-04-06(xsd:dateTime)
bibo:doi	10.14283/jpad.2020.18
bibo:pmid	32420298
has license	no-cc
sha1sum (hex)	e9afd27fe49ea627f9eafb4ac78a1f324aaafed0
schema:url	https://doi.org/10.14283/jpad.2020.18
resource representing a document's title	Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report
has PubMed Central identifier	PMC7223540
has PubMed identifier	32420298

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