About: Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets

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About: Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets
Creator	Andrés-Lasheras, Sara Bolea, Rosa Chirino-Trejo, Manuel Kuijper, Ed Martín-Burriel, Inma Morales, Mariano Blanco, José Carlos Mainar-Jaime, Raúl
Source	Medline; PMC
abstract	BACKGROUND: Clostridium difficile infection (CDI) is recognised as an emerging disease in both humans and some animal species. During the past few years, insights into human CDI epidemiology changed and C. difficile is also considered as an emerging community-acquired pathogen. Certain ribotypes (RT) are possibly associated with zoonotic transmission. The objective of this study was to assess the presence of C. difficile in a population of pets and to characterise the isolates. RESULTS: Faecal samples from a total of 90 diarrhoeic dogs and 24 from exotic animal species (both diarrhoeic and non-diarrhoeic) were analysed. Clostridium difficile was isolated from 6 (6.7%) dogs and one reptile sample (4.2%). Four (66.7%) of the six dog strains were capable of producing toxins. Four known different RTs were detected in dogs (010, 014, 123 and 358) and a new one was found in a faecal sample of an exotic animal. This new RT isolate was negative for all toxin genes tested and belonged to sequence type 347 which has been proposed as a Clade-III member. Importantly, two dog strains showed a stable resistance to metronidazole (initial MIC values: 128 and 48 μg/ml). CONCLUSIONS: The results obtained in this study suggest the implementation of antimicrobial susceptibility surveillance programs to assess the prevalence of metronidazole resistance in dogs; molecular studies to elucidate C. difficile metronidazole resistance mechanisms are warranted. Based on the similarity between the ribotypes observed in dogs and those described in humans, the zoonotic transmission should be further explored. Furthermore, exotic animals have shown to harbor uncommon C. difficile strains which require further genomic studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-018-1402-7) contains supplementary material, which is available to authorized users.
has issue date	2018-03-09(xsd:dateTime)
bibo:doi	10.1186/s12917-018-1402-7
bibo:pmid	29523201
has license	cc-by
sha1sum (hex)	e990cc7120ae9e3ef809a225842f9d110f38b042
schema:url	https://doi.org/10.1186/s12917-018-1402-7
resource representing a document's title	Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets
has PubMed Central identifier	PMC5845233
has PubMed identifier	29523201
schema:publication	BMC Vet Res
resource representing a document's body	covid:e990cc7120ae9e3ef809a225842f9d110f38b042#body_text
is schema:about of	named entity 'The' named entity 'species' named entity 'dogs' named entity 'isolates' named entity 'PRELIMINARY' named entity 'PETS' named entity 'YEARS' named entity 'HUMAN' named entity 'CONSIDERED' named entity 'HUMANS' named entity 'C. DIFFICILE' named entity 'PROPOSED' named entity 'FOUND' named entity 'ASSOCIATED WITH' named entity 'DOGS' named entity 'POSSIBLY' named entity 'TRANSMISSION' named entity 'ISOLATED' named entity 'STUDY' named entity 'NEGATIVE' named entity 'TOXIN' named entity 'PAST' named entity 'PETS' named entity 'ACQUIRED' named entity 'STUDIES' named entity 'ISOLATES' named entity 'SAMPLES' named entity 'RESISTANCE TO' named entity 'DETECTED' named entity 'EXOTIC' named entity 'CLOSTRIDIUM DIFFICILE' named entity 'DOGS' named entity 'INSIGHTS' named entity 'TOXINS' named entity 'KNOWN' named entity 'METRONIDAZOLE' named entity 'TESTED' named entity 'PRESENCE OF' named entity 'VALUES' named entity 'GENES' named entity 'CLADE' named entity 'MEMBER' named entity 'EXOTIC' named entity 'PRODUCING' named entity 'STRAINS' named entity 'NON-' named entity 'CLOSTRIDIUM DIFFICILE' named entity 'POPULATION' named entity 'CHANGED' named entity 'RESULTS' named entity 'DISEASE' named entity 'CERTAIN' named entity 'COMMUNITY' named entity 'REPTILE' named entity 'STABLE' named entity 'CLOSTRIDIUM DIFFICILE INFECTION' named entity 'DIFFERENT' named entity 'SAMPLE' named entity 'OBJECTIVE' named entity 'III' named entity 'ISOLATE' named entity 'ANIMAL SPECIES' named entity 'MIC' named entity 'PATHOGEN' named entity 'CAPABLE' named entity 'SEQUENCE TYPE' named entity 'ISOLATES' named entity 'EPIDEMIOLOGY' named entity 'ZOONOTIC' named entity 'BACKGROUND' named entity 'FAECAL' named entity 'RTS' named entity 'CDI' named entity 'DOG'

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