About: Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera

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About: Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera
Creator	Al Talla, Zeyad Almulhim, Fatimah Boughattas, Naceur Dhahri, Manel Dridi, Rihab Emwas, Abdul-Hamid Hassine, Mohsen Jaremko, Mariusz Sioud, Salim
Source	Medline; PMC
abstract	[Image: see text] Bioactive compounds for drug discovery are increasingly extracted and purified from natural sources including marine organisms. Heparin is a therapeutic agent that has been used for several decades as an anticoagulant. However, heparin is known to cause many undesirable complications such as thrombocytopenia and risk of hemorrhage. Hence, there is a need to find alternatives to current widely used anticoagulant drugs. Here, we extract a sulfated polysaccharide from sea hare, that is, Bursatella leachii viscera, by enzymatic digestion. Several analytical approaches including elemental analysis, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and high-performance liquid chromatography–mass spectrometry analysis show that B. leachii polysaccharides have chemical structures similar to glycosaminoglycans. We explore the anticoagulant activity of the B. leachii extract using the activated partial thromboplastin time and the thrombin time. Our results demonstrate that the extracted sulfated polysaccharide has heparin-like anticoagulant activity, thus showing great promise as an alternative anticoagulant therapy.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1021/acsomega.0c01724
bibo:pmid	32596616
has license	no-cc
sha1sum (hex)	e92b69636c08f8cd0bf8ea065e0342d3bbb06d9c
schema:url	https://doi.org/10.1021/acsomega.0c01724
resource representing a document's title	Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera
has PubMed Central identifier	PMC7315596
has PubMed identifier	32596616
schema:publication	ACS Omega
resource representing a document's body	covid:e92b69636c08f8cd0bf8ea065e0342d3bbb06d9c#body_text
is schema:about of	named entity 'anticoagulant' named entity 'activity' named entity 'alternatives' named entity 'Characterization' named entity 'VISCERA' named entity 'ALTERNATIVE' named entity 'OUR' named entity 'PURIFIED' named entity 'POLYSACCHARIDES' named entity 'ANALYSIS' named entity 'CURRENT' named entity 'EXTRACT' named entity 'polysaccharide' named entity 'extracted' named entity 'anticoagulant' named entity 'explore' named entity 'decades' named entity 'hemorrhage' named entity 'Heparin' named entity 'heparin' named entity 'therapeutic agent' named entity 'glycosaminoglycans' named entity 'thrombocytopenia' named entity 'polysaccharide' named entity 'enzymatic digestion' named entity 'Viscera' named entity 'Polysaccharide' named entity 'extract' named entity 'mol/L' named entity 'arg' named entity 'Milli-Q water' named entity 'sea hare' named entity 'GlcA' named entity 'nitrogen' named entity 'polysaccharide' named entity 'hydrogen' named entity 'polysaccharide' named entity 'marine origin' named entity 'polysaccharide' named entity 'invasive species' named entity 'hydroxyl groups' named entity 'pacu' named entity 'polysaccharide' named entity 'gel permeation chromatography' named entity 'ppm' named entity 'polyanionic' named entity 'cetyltrimethylammonium bromide' named entity 'Bruker' named entity 'marine organisms' named entity 'COVID-19' named entity 'bioactivities' named entity 'methyl' named entity 'polysaccharide' named entity 'chemical structure' named entity 'dialysis' named entity 'molecular dynamics' named entity 'polysaccharide' named entity 'Bruker Daltonics' named entity 'anticoagulant' named entity 'N-acetylgalactosamine' named entity 'nitrogen' named entity 'drug candidate' named entity 'digestion' named entity 'polysaccharide' named entity 'electropherogram' named entity 'centrifuged' named entity 'electrophoresis' named entity '99.9%' named entity 'sodium citrate' named entity 'polysaccharides' named entity 'sea hare' named entity 'polysaccharide' named entity 'sulfur'

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