About: 10 Impacts of virus-mediated manipulation of host Dynein

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: 10 Impacts of virus-mediated manipulation of host Dynein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	10 Impacts of virus-mediated manipulation of host Dynein
Creator	Berthoux, Lionel Yao, Xaojian Milev, Miroslav Mouland, Andrew
Source	Elsevier; PMC
abstract	Abstract In general viruses' modus operandi to propagate is achieved by the co-opting host cell components, membranes, proteins, and machineries to their advantage. This is true for virtually every aspect of a virus' replication cycle from virus entry to the budding or release of progeny virus particles. In this chapter, we will discuss new information on the impacts of virus-mediated manipulation of Dynein motor complexes and associated machineries and factors. We will highlight how these host cell components impact on pathogenicity and immune responses, as many of the virus-mediated hijacked components also play pivotal roles in immune responses to pathogen insult. There are several comprehensive reviews that define virus–Dynein interactions including the first edition of this book that describes how viruses manipulate the host cell machineries their advantage. An updated table is included to summarize these virus–host interactions. Notably, barriers to intracellular translocation represent major hurdles to viral components during de novo infection and during active replication and the generation of progeny virus particles. Clearly, the subversion of host cell molecular motor protein activities takes advantage of constitutive and regulated membrane trafficking events and will target virus components to intracytoplasmic locales and membrane assembly. Broadening our understanding of the interplay between viruses, Dynein and the cytoskeleton will likely inform on new types of therapies. Continual enhancement of the breadth of new information on how viruses manipulate host cell biology will inevitably aid in the identification of new targets that can be poisoned to block old, new, and emerging viruses alike in their tracks.
has issue date	2018-12-31(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-809470-9.00010-2
has license	els-covid
sha1sum (hex)	e906a00291d17be5e5f184cb5cae1930827db2b3
schema:url	https://doi.org/10.1016/b978-0-12-809470-9.00010-2
resource representing a document's title	10 Impacts of virus-mediated manipulation of host Dynein
has PubMed Central identifier	PMC7150161
schema:publication	Dyneins
resource representing a document's body	covid:e906a00291d17be5e5f184cb5cae1930827db2b3#body_text
is schema:about of	named entity 'Fasciculation' named entity 'Kinesin' named entity 'virus' named entity 'Rab5' named entity 'Dynactin' named entity 'retrograde transport' named entity 'uncoating' named entity 'MSP' named entity 'critical role' named entity 'lysosomal' named entity 'herpes simplex virus' named entity 'active transport' named entity 'Dynein motor complex' named entity 'viruses' named entity 'expression levels' named entity 'antiviral' named entity 'organelles' named entity 'cytoskeletal elements' named entity 'Dynein' named entity 'TRIM5α' named entity 'phosphoprotein' named entity 'capsid' named entity 'intracellular' named entity 'vesicles' named entity 'macrophages' named entity 'retrograde transport' named entity 'VAP-A' named entity 'late endosome' named entity 'TRIM5α' named entity 'lentivirus' named entity 'murine leukemia virus' named entity 'mutants' named entity 'endosomal' named entity 'Rab7' named entity 'viral proteins' named entity 'cholesterol' named entity 'Dynein' named entity 'Dynein' named entity 'viruses' named entity 'flaviviridae' named entity 'protein' named entity 'Tetherin' named entity 'HIV-1' named entity 'lysosomes' named entity 'pathogen' named entity 'fluorescently' named entity 'HIV-1' named entity 'viral entry' named entity 'retrograde transport' named entity 'live cell microscopy' named entity 'lipid raft' named entity 'CD4 +' named entity 'parvoviruses' named entity 'translocation' named entity 'acetylation' named entity 'antiviral' named entity 'viral proteins' named entity 'posttranslationally modified' named entity 'nocodazole' named entity 'VAP-A' named entity 'reverse transcription' named entity 'HCV' named entity 'retroviruses' named entity 'binding proteins' named entity 'pattern recognition receptors' named entity 'Dengue' named entity 'virus-mediated' named entity 'protein' named entity 'virus-mediated' named entity 'HIV-1' named entity 'reverse transcription' named entity 'infectivity' named entity 'virus' named entity 'transmembrane protein' named entity 'protein' named entity 'cytoplasmic' named entity 'Dynein' named entity 'Kinesin' named entity 'gene product' named entity 'cofactors'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software