About: Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides
Creator	Wengel, Jesper Jha, Amitabh Kaushik, Kumar Kumar, Vineet Len, Christophe Sharma, Deepti Yadav, Yogesh Malhotra, Sanjay Parmar, Virinder Prasad, Ashok
Source	PMC
abstract	The synthesis of novel pyrazolylnucleosides 3a–e, 4a–e, 5a–e, and 6a–e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a–e and 6a–e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI(50) 9.3 µM) and breast cancer cell line HS 578T (GI(50) 3.0 µM).
has issue date	2019-10-30(xsd:dateTime)
bibo:doi	10.3390/molecules24213922
bibo:pmid	31671703
has license	cc-by
sha1sum (hex)	e8d7fb48d727d602587af256f10d5b389af1d7a1
schema:url	https://doi.org/10.3390/molecules24213922
resource representing a document's title	Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides
has PubMed Central identifier	PMC6864788
has PubMed identifier	31671703
schema:publication	Molecules
resource representing a document's body	covid:e8d7fb48d727d602587af256f10d5b389af1d7a1#body_text
is schema:about of	named entity 'NOVEL' covid:arg/e8d7fb48d727d602587af256f10d5b389af1d7a1 named entity 'SYNTHESIS' named entity 'TUMOR CELL LINES' named entity 'USING' named entity 'ACTIVITY' named entity 'BREAST CANCER CELL LINE' named entity 'ACTIVITIES' named entity 'HOP-92' named entity 'DESCRIBED' named entity 'SIXTY' named entity 'PARTICULAR' named entity 'LUNG CANCER CELL LINE' named entity 'EXTENSIVE' named entity 'INHIBITION' named entity 'SIGNIFICANT' named entity 'HUMAN' named entity 'ANTICANCER' named entity 'SYNTHETIC' named entity 'CANCER CELL LINES' named entity 'HS 578T' named entity 'STRUCTURAL' named entity 'STRUCTURES' named entity 'GOOD' named entity 'COMPOUND' named entity 'ANTICANCER' named entity 'ACTIVITY' named entity 'EVALUATION STUDIES' named entity 'MOLECULES' named entity 'NMR' named entity 'STUDIES' named entity 'NOVEL' named entity 'cell line' named entity 'cancer cell lines' named entity 'pyrazole' named entity 'N-1' named entity 'Merck' named entity 'acetonitrile' named entity 'chloroform' named entity 'Bruker' named entity 'carbon' named entity 'nucleosides' named entity 'silica gel' named entity 'HMBC' named entity 'nucleosides' named entity 'Billerica' named entity 'H-NMR' named entity 'pyrazole' named entity 'gene' named entity 'methanol' named entity 'lung cancer' named entity 'HSQC' named entity 'acetonitrile' named entity 'cell line' named entity 'corona virus' named entity 'mmol' named entity 'pyrazofurin' named entity 'positive ion' named entity 'virus' named entity 'active compound' named entity 'anti-sense' named entity 'viruses' named entity '4a-e' named entity 'nucleosides' named entity 'pyrazole' named entity 'drug resistance' named entity 'chloride' named entity 'NOESY' named entity 'AIDS' named entity 'Vaccinia virus' named entity 'nucleotides' named entity 'HMBC'

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